137977-41-4

Basic information

• Product Name: 8-chloro-1-[4-[(2-methylbenzoyl)amino]benzoyl]-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine
• Synonyms: 8-chloro-1-[4-[(2-methylbenzoyl)amino]benzoyl]-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine
• CAS NO: 137977-41-4
• Molecular Weight: 432.906
• Mol File: 137977-41-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 8-chloro-1-[4-[(2-methylbenzoyl)amino]benzoyl]-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine(CAS DataBase Reference)
• NIST Chemistry Reference: 8-chloro-1-[4-[(2-methylbenzoyl)amino]benzoyl]-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine(137977-41-4)
• EPA Substance Registry System: 8-chloro-1-[4-[(2-methylbenzoyl)amino]benzoyl]-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine(137977-41-4)

Safety Data

• Hazardous Substances Data: 137977-41-4(Hazardous Substances Data)

Upstream product

• 933-88-0 ortho-toluoyl chloride 
• 137984-96-4 1-(4-aminobenzoyl)-8-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine 
• 5900-58-3 2-amino-4-chloro-benzoic acid methyl ester 
• 38314-49-7 8-chloro-5-oxo-2,3,4,5-tetrahydro-1-p-toluenesulfonyl-1H-1-benzazepine 
• 6280-88-2 4-chloro-2-nitro-benzoic acid 
• 29247-79-8 N-p-toluenesulfonyl-4-chloro-anthranilic acid methyl ester 
• 38314-47-5 methyl 4-chloro-2-[N-(3-ethoxycarbonyl)propyl-N-p-toluenesulfonyl]aminobenzoate 
• 42087-80-9 methyl 4-chloro-2-nitrobenzoate 
• 122-04-3 4-nitro-benzoyl chloride 
• 116815-03-3 8-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one 
• 137984-93-1 8-chloro-1-(4-nitrobenzoyl)-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine 

Downstream Products

• 154890-41-2 8-chloro-5-(N-methylamino)-1-[4-[(2-methylbenzoyl)amino]benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine 

Relevant articles and documents

7-Chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5- tetrahydro-1H-1-benzazepine (OPC-41061): A potent, orally active nonpeptide arginine vasopressin V2 receptor antagonist

We previously reported a series of benzazepine derivatives as orally active nonpeptide arginine vasopressin (AVP) V2 receptor antagonists. After the lead structure OPC-31260 was structurally evaluated and optimized, the introduction of the 7-Cl moiety on the benzazepine and 2-CH3 on the aminobenzoyl moiety enhanced its oral activity. The new AVP-V2 selective antagonist OPC-41061 was determined to be a potent and orally active agent. Copyright (C) 1999 Elsevier Science Ltd.