383180-98-1

Basic information

• Product Name: Silane, [[3,5-dichloro-4-(4-nitrophenoxy)phenyl]ethynyl]trimethyl-
• CAS NO: 383180-98-1
• Molecular Formula: C17H15Cl2NO3Si
• Molecular Weight: 380.303
• Mol File: 383180-98-1.mol

Chemical Properties

• CAS DataBase Reference: Silane, [[3,5-dichloro-4-(4-nitrophenoxy)phenyl]ethynyl]trimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Silane, [[3,5-dichloro-4-(4-nitrophenoxy)phenyl]ethynyl]trimethyl-(383180-98-1)
• EPA Substance Registry System: Silane, [[3,5-dichloro-4-(4-nitrophenoxy)phenyl]ethynyl]trimethyl-(383180-98-1)

Safety Data

• Hazardous Substances Data: 383180-98-1(Hazardous Substances Data)

Upstream product

• 383180-97-0 5-bromo-1,3-dichloro-2-(4-nitrophenoxy)-benzene 
• 1066-54-2 trimethylsilylacetylene 
• 87-65-0 2,6-Dichlorophenol 
• 3217-15-0 4-bromo-2,6-dichloro-phenol 

Downstream Products

• 383181-04-2 [4-(3-bromo-4-isobutyrylamino-phenoxy)-3,5-dichloro-phenyl]-acetic acid methyl ester 
• 383181-03-1 methyl [4-(4-amino-3-bromo-phenoxy)-3,5-dichlorophenyl]acetate 
• 957828-46-5 [3,5-dichloro-4-(4-nitro-phenoxy)-phenyl]-acetic acid 
• 383180-99-2 [3,5-dichloro-4-(4-nitrophenoxy)-phenyl]-acetic acid methyl ester 
• 383181-02-0 [4-(4-aminophenoxy)-3,5-dichloro-phenyl]-acetic acid methyl ester 
• 957828-45-4 1,3-Dichloro-5-ethynyl-2-(4-nitro-phenoxy)-benzene 

Relevant articles and documents

Thyroid receptor ligands. Part 4: 4′-amido bioisosteric ligands selective for the thyroid hormone receptor beta

Based on the examination of the X-ray crystallographic structures of the LBD of TRα and TRβ in complex with KB-141 (2), a number of novel 4′-hydroxy bioisosteric thyromimetics were prepared. Optimal affinity and β-selectivity (33 times), was found with a medium-sized alkyl-substituted amido group; iso-butyl (12c). It can be concluded that bioisosteric replacements of the 4′-hydroxy position represent a new promising class of TRβ-selective synthetic thyromimetics.

INDOLE DERIVATIVES AND THEIR USE AS THYROID RECEPTOR LIGANDS

The invention provides compounds of formula (I) or pharmaceutically acceptable esters, amides, solvates or salts thereof, including salts of such esters or amides, and solvates of such esters, amides or salts, (I) wherein R1, R2, R3, R4, R5, R6, Y and W are as defined in the specification. The invention also provides the use of such compounds in the treatment or prophylaxis of a condition that may be treated with a thyroid receptor agonist or partial agonist.