957828-45-4

Basic information

• Product Name: 1,3-Dichloro-5-ethynyl-2-(4-nitro-phenoxy)-benzene
• CAS NO: 957828-45-4
• Molecular Weight: 308.12
• Mol File: 957828-45-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,3-Dichloro-5-ethynyl-2-(4-nitro-phenoxy)-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dichloro-5-ethynyl-2-(4-nitro-phenoxy)-benzene(957828-45-4)
• EPA Substance Registry System: 1,3-Dichloro-5-ethynyl-2-(4-nitro-phenoxy)-benzene(957828-45-4)

Safety Data

• Hazardous Substances Data: 957828-45-4(Hazardous Substances Data)

Upstream product

• 3217-15-0 4-bromo-2,6-dichloro-phenol 
• 87-65-0 2,6-Dichlorophenol 
• 383180-97-0 5-bromo-1,3-dichloro-2-(4-nitrophenoxy)-benzene 
• 383180-98-1 [3,5-dichloro-4-(4-nitro-phenoxy)-phenylethynyl]-trimethylsilane 

Downstream Products

• 383181-02-0 [4-(4-aminophenoxy)-3,5-dichloro-phenyl]-acetic acid methyl ester 
• 383180-99-2 [3,5-dichloro-4-(4-nitrophenoxy)-phenyl]-acetic acid methyl ester 
• 383181-03-1 methyl [4-(4-amino-3-bromo-phenoxy)-3,5-dichlorophenyl]acetate 
• 383181-04-2 [4-(3-bromo-4-isobutyrylamino-phenoxy)-3,5-dichloro-phenyl]-acetic acid methyl ester 
• 957828-46-5 [3,5-dichloro-4-(4-nitro-phenoxy)-phenyl]-acetic acid 

Relevant articles and documents

Thyroid receptor ligands. Part 4: 4′-amido bioisosteric ligands selective for the thyroid hormone receptor beta

Based on the examination of the X-ray crystallographic structures of the LBD of TRα and TRβ in complex with KB-141 (2), a number of novel 4′-hydroxy bioisosteric thyromimetics were prepared. Optimal affinity and β-selectivity (33 times), was found with a medium-sized alkyl-substituted amido group; iso-butyl (12c). It can be concluded that bioisosteric replacements of the 4′-hydroxy position represent a new promising class of TRβ-selective synthetic thyromimetics.