383181-49-5

Upstream product

• 383181-48-4 1,3-dibromo-5-fluoro-2-(4-nitrophenoxy)benzene 
• 124-41-4 sodium methylate 

Downstream Products

• 918946-12-0 methyl [4-(4-aminophenoxy)-3,5-dibromophenoxy]acetate 
• 383181-51-9 3,5-dibromo-4-(4-nitrophenoxy) phenol 
• 383181-52-0 ethyl [3,5-dibromo-4-(4-nitrophenoxy)phenoxy]acetate 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUNDS AS AGONISTS FOR THE THYROID RECEPTOR

The invention provides Compounds of formula (I) or pharmaceutically acceptable esters, amides, solvates or salts thereof, including salts of such esters or amides, and solvates of such esters, amides or salts, wherein R3, R4, G, Y, W and R5 are as defined in the specification. The invention also provides the use of such Compounds in the treatment or Prophylaxis of a condition associated with a disease or disorder associated with thyroid receptor activity.

NOVEL PHARMACEUTICAL COMPOSITIONS

The invention provides the use of compounds of formula (I) or pharmaceutically acceptable esters, amides, solvates or salts thereof, including salts of such esters or amides, and solvates of such esters, amides or salts, for the manufacture of a medicament for the treatment or prophylaxis of a condition that may be treated with a thyroid receptor agonist or partial agonist wherein R1, R2, R3, R4, Y, W and R5 are as defined in the specification. The invention also provides compounds of formula (Ia) or pharmaceutically acceptable esters, amides, solvates or salts thereof, including salts of such esters or amides, and solvates of such esters, amides or salts, formula (Ia) wherein R1, R2, R3, R4, Y, W and R5 are as defined in the specification.

INDOLE DERIVATIVES AND THEIR USE AS THYROID RECEPTOR LIGANDS

The invention provides compounds of formula (I) or pharmaceutically acceptable esters, amides, solvates or salts thereof, including salts of such esters or amides, and solvates of such esters, amides or salts, (I) wherein R1, R2, R3, R4, R5, R6, Y and W are as defined in the specification. The invention also provides the use of such compounds in the treatment or prophylaxis of a condition that may be treated with a thyroid receptor agonist or partial agonist.

Thyroid receptor ligands, pharmaceutical compositions comprising them and their use in the treatment of disorders influenced by thyroid hormones

This invention relates to compounds of the formula (I) which are thyroid receptor ligands, and are preferably selective for the thyroid hormone receptor β, to methods of preparing such compounds and to methods for using such compounds such as in the regulation of metabolism.