38319-40-3Relevant academic research and scientific papers
Synthesis, spectroscopic and structural studies of new 2-substituted 4-nitroimidazoles
Alliouche, Hayette,Bouraiou, Abdelmalek,Bouacida, Sofiane,Bahnous, Mebarek,Roisnel, Thierry,Belfaitah, Ali
, p. 174 - 179 (2014/05/20)
This study describes the synthesis of novel 4-nitro-2-substitutedimidazole derivatives via a transposition reaction of nitro group. Conversion of 5-nitro-2-phenylethanol (styryl) imidazole derivatives into the corresponding 4- nitroisomers was achieved in good yields in nitrobenzene using a catalytic amount of methyl iodide. Spectroscopic study and single crystal X-ray structures are reported for five compounds to understand the conformational structures of these compounds.
Synthesis and electrochemistry of 2-ethenyl and 2-ethanyl derivatives of 5-nitroimidazole and antimicrobial activity against Giardia lamblia
Valdez, Carlos A.,Tripp, Jonathan C.,Miyamoto, Yukiko,Kalisiak, Jaroslaw,Hruz, Petr,Andersen, Yolanda S.,Brown, Sabrina E.,Kangas, Karina,Arzu, Leo V.,Davids, Barbara J.,Gillin, Frances D.,Upcroft, Jacqueline A.,Upcroft, Peter,Fokin, Valery V.,Smith, Diane K.,Sharpless, K. Barry,Eckmann, Lars
experimental part, p. 4038 - 4053 (2009/12/28)
Infections with the diarrheagenic pathogen, Giardia lamblia, are commonly treated with the 5-nitroimidazole (5-NI) metronidazole (Mz), and yet treatment failures and Mz resistance occur. Using a panel of new 2-ethenyl and 2-ethanyl 5-NI derivatives, we fo
