383199-89-1Relevant articles and documents
Development of a pilot-scale preparation of N-[[(5S)-3-[4-(1,1-dioxido-4- thiomorpholinyl)-3,5-difluorophenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide, PNU-288034, an oxazolidinone antibacterial agent
Lu, Cuong V.,Chen, Jiong J.,Perrault, William R.,Conway, Brian G.,Maloney, Mark T.,Wang, Ying
, p. 272 - 277 (2012/12/22)
As part of Pfizer's continuing efforts in the oxazolidinone area, we have developed an efficient synthesis of PNU-288034 and successfully implemented it on pilot scale. The key step was a novel, acid-catalyzed, double Michael addition of 2,6-difluoroanili
N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
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Page 47, (2010/02/07)
The present invention provides antibacterial agents having the formulae I, II, and III described herein.
Catalyzed double Michael addition of anilines to vinyl sulfone
Chen, Jiong Jack,Lu, Cuong V.,Brockman, Rebecca N.
, p. 3459 - 3462 (2007/10/03)
Substituted anilines and vinyl sulfone undergo a facile double Michael addition to form substituted phenylthiomorpholine dioxide, catalyzed with AlCl3 or H3PO4. Scope and conditions were explored.