383199-89-1Relevant academic research and scientific papers
Development of a pilot-scale preparation of N-[[(5S)-3-[4-(1,1-dioxido-4- thiomorpholinyl)-3,5-difluorophenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide, PNU-288034, an oxazolidinone antibacterial agent
Lu, Cuong V.,Chen, Jiong J.,Perrault, William R.,Conway, Brian G.,Maloney, Mark T.,Wang, Ying
, p. 272 - 277 (2012/12/22)
As part of Pfizer's continuing efforts in the oxazolidinone area, we have developed an efficient synthesis of PNU-288034 and successfully implemented it on pilot scale. The key step was a novel, acid-catalyzed, double Michael addition of 2,6-difluoroanili
Amide-containing compound having improved solubility and method of improving the solubility of an amide-containing compound
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Page 63, (2010/02/05)
The present invention is directed to novel amide-containing compounds which have an improved solubility and a method of improving the solubility of amide-containing compounds. The amide-containing compounds include oxazolidinone compounds and the bioavail
N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
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Page 47, (2010/02/07)
The present invention provides antibacterial agents having the formulae I, II, and III described herein.
Catalyzed double Michael addition of anilines to vinyl sulfone
Chen, Jiong Jack,Lu, Cuong V.,Brockman, Rebecca N.
, p. 3459 - 3462 (2007/10/03)
Substituted anilines and vinyl sulfone undergo a facile double Michael addition to form substituted phenylthiomorpholine dioxide, catalyzed with AlCl3 or H3PO4. Scope and conditions were explored.
Method for the preparation of oxazolidinones
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, (2008/06/13)
The present invention relates to a method for the production of N-({(5S)-3-[4-(1,1-dioxido-4-thiomorpholinyl)-3,5-difluorophenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide or its pharmaceutically acceptable salt.
N-ARYL-2-OXAZOLIDINONE-5-CARBOXAMIDES AND THEIR DERIVATIVES AND THEIR USE AS ANTIBACTERIALS
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Page/Page column 91, (2010/02/07)
Compounds of formula B-C-A-CO-NH-R1, wherein A is structure i, ii or iii: formulae (I), (II), (III). C is optionally substituted aryl or heteroaryl, and B is a specified cyclic moiety, or C and B together are a heterobicyclic moiety, are useful as antibacterial agents.
