383199-91-5

Basic information

• Product Name: 4-(1,1-dioxidothiomorpholin-4-yl)-3,5-difluoroaniline
• CAS NO: 383199-91-5
• Molecular Formula: C₁₀H₁₂F₂N₂O₂S
• Molecular Weight: 262.2763
• Mol File: 383199-91-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 507.767°C at 760 mmHg
• Flash Point: 260.888°C
• Density: 1.465g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.583
• CAS DataBase Reference: 4-(1,1-dioxidothiomorpholin-4-yl)-3,5-difluoroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1,1-dioxidothiomorpholin-4-yl)-3,5-difluoroaniline(383199-91-5)
• EPA Substance Registry System: 4-(1,1-dioxidothiomorpholin-4-yl)-3,5-difluoroaniline(383199-91-5)

Safety Data

• Hazardous Substances Data: 383199-91-5(Hazardous Substances Data)

Upstream product

• 5509-65-9 2,6-difluoroaniline 
• 383199-89-1 4-(2,6-difluorophenyl)thiomorpholine 1,1-dioxide 
• 383199-90-4 4-(2,6-difluoro-4-nitrophenyl)thiomorpholine-1,1-dioxide 

Downstream Products

• 473871-38-4 isobutyl 4-(1,1-dioxidothiomorpholin-4-yl)-3,5-difluorophenylcarbamate 
• 590421-58-2 methyl (2R)-3-{[4-(1,1-dioxidothiomorpholin-4-yl)-3,5-difluorophenyl]amino}-2-hydroxypropanoate 

Relevant articles and documents

Development of a pilot-scale preparation of N-[[(5S)-3-[4-(1,1-dioxido-4- thiomorpholinyl)-3,5-difluorophenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide, PNU-288034, an oxazolidinone antibacterial agent

As part of Pfizer's continuing efforts in the oxazolidinone area, we have developed an efficient synthesis of PNU-288034 and successfully implemented it on pilot scale. The key step was a novel, acid-catalyzed, double Michael addition of 2,6-difluoroanili

N-aryl-2-oxazolidinone-5-carboxamides and their derivatives

The present invention provides antibacterial agents having the formulae I, II, and III described herein.

N-ARYL-2-OXAZOLIDINONE-5-CARBOXAMIDES AND THEIR DERIVATIVES AND THEIR USE AS ANTIBACTERIALS

Compounds of formula B-C-A-CO-NH-R1, wherein A is structure i, ii or iii: formulae (I), (II), (III). C is optionally substituted aryl or heteroaryl, and B is a specified cyclic moiety, or C and B together are a heterobicyclic moiety, are useful as antibacterial agents.