3832-24-4

Basic information

• Product Name: 3,3,3-TRIFLUORO-2-HYDROXYPROPYLAMINE HYDROCHLORIDE
• Synonyms: 3,3,3-TRIFLUORO-2-HYDROXYPROPYLAMINE HYDROCHLORIDE;3,3,3-TRIFLUORO-2-HYDROXYPROPYLAMINE HYDROCHLORIDE, 97% MIN.;2-Hydroxy-3,3,3-trifluoropropylamine hydrochloride;3-Amino-1,1,1-trifluoropropan-2-ol hydrochloride 97+%;3-Amino-1,1,1-trifluoropropan-2-ol hydrochloride
• CAS NO: 3832-24-4
• Molecular Formula: C₃H₆F₃NO*ClH
• Molecular Weight: 165.54
• Mol File: 3832-24-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 176.5 °C at 760 mmHg
• Flash Point: 60.5 °C
• Appearance: /
• Density: 1.344 g/cm³
• Vapor Pressure: 0.0308mmHg at 25°C
• CAS DataBase Reference: 3,3,3-TRIFLUORO-2-HYDROXYPROPYLAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3,3-TRIFLUORO-2-HYDROXYPROPYLAMINE HYDROCHLORIDE(3832-24-4)
• EPA Substance Registry System: 3,3,3-TRIFLUORO-2-HYDROXYPROPYLAMINE HYDROCHLORIDE(3832-24-4)

Safety Data

• Hazardous Substances Data: 3832-24-4(Hazardous Substances Data)

Usage

General Description

3,3,3-TRIFLUORO-2-HYDROXYPROPYLAMINE HYDROCHLORIDE is a chemical compound that features a trifluoromethyl group attached to a hydroxypropylamine unit. It is commonly used as a reagent in organic synthesis and pharmaceutical manufacturing. The hydrochloride salt form of this compound is water soluble and can be used as a precursor for the synthesis of various organic compounds. It has also been studied for its potential application in the development of fluorinated pharmaceuticals and agrochemicals. Additionally, it is known for its potential as a building block in the synthesis of complex organic molecules, including those with biological activity.

InChI:InChI=1/C3H6F3NO.ClH/c4-3(5,6)2(8)1-7;/h2,8H,1,7H2;1H

Relevant articles and documents

Lewis Acid-Catalyzed Addition of Benzophenone Imine to Epoxides Enables the Selective Synthesis and Derivatization of Primary 1,2-Amino Alcohols

Benzophenone imine was found to be an effective ammonia surrogate for the selective preparation of primary 1,2-amino alcohols from epoxides, including enantiopure epichlorohydrin, in the presence of catalytic Y(OTf)3. High-throughput screening of 48 Lewis acids quickly identified Y(OTf)3 as an effective mediator of the addition reaction under mild conditions. Following acidic hydrolysis, the primary amino alcohol salt is revealed and partitions into the aqueous solution, while the benzophenone byproduct is easily removed by simple extraction with ethyl acetate. These ammonium salts can be directly Boc-protected or further derivatized without isolation to form benzamides and sulfonamides under Schotten-Baumann-type conditions in up to 79% isolated yield over three steps. This methodology has been used to prepare key intermediates for the synthesis of PRMT5 inhibitors with high enantiopurity as well as numerous other amide and sulfonamide derivatives.