3832-24-4 Usage
Uses
Used in Organic Synthesis:
3,3,3-TRIFLUORO-2-HYDROXYPROPYLAMINE HYDROCHLORIDE is used as a reagent for the synthesis of various organic compounds, leveraging its unique structural features to facilitate chemical reactions and the formation of new molecular entities.
Used in Pharmaceutical Manufacturing:
In the pharmaceutical industry, 3,3,3-TRIFLUORO-2-HYDROXYPROPYLAMINE HYDROCHLORIDE serves as a precursor in the development of new drugs, particularly those that require the introduction of fluorine atoms for enhanced pharmacokinetic and pharmacodynamic properties.
Used in Fluorinated Pharmaceutical Development:
3,3,3-TRIFLUORO-2-HYDROXYPROPYLAMINE HYDROCHLORIDE is utilized as a key intermediate in the synthesis of fluorinated pharmaceuticals, where the presence of fluorine can significantly influence the drug's metabolic stability, lipophilicity, and receptor binding affinity.
Used in Agrochemical Production:
3,3,3-TRIFLUORO-2-HYDROXYPROPYLAMINE HYDROCHLORIDE is also applied in the agrochemical sector, where it is used as a building block for the synthesis of new pesticides and other agrochemicals, potentially improving their effectiveness and selectivity.
Used in the Synthesis of Biologically Active Molecules:
3,3,3-TRIFLUORO-2-HYDROXYPROPYLAMINE HYDROCHLORIDE is employed as a component in the assembly of complex organic molecules with biological activity, contributing to the discovery and development of novel therapeutic agents and bioactive compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 3832-24-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,8,3 and 2 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 3832-24:
(6*3)+(5*8)+(4*3)+(3*2)+(2*2)+(1*4)=84
84 % 10 = 4
So 3832-24-4 is a valid CAS Registry Number.
InChI:InChI=1/C3H6F3NO.ClH/c4-3(5,6)2(8)1-7;/h2,8H,1,7H2;1H
3832-24-4Relevant academic research and scientific papers
Lewis Acid-Catalyzed Addition of Benzophenone Imine to Epoxides Enables the Selective Synthesis and Derivatization of Primary 1,2-Amino Alcohols
Leitch, David C.,Lim, John Jin
, p. 641 - 649 (2018/05/14)
Benzophenone imine was found to be an effective ammonia surrogate for the selective preparation of primary 1,2-amino alcohols from epoxides, including enantiopure epichlorohydrin, in the presence of catalytic Y(OTf)3. High-throughput screening of 48 Lewis acids quickly identified Y(OTf)3 as an effective mediator of the addition reaction under mild conditions. Following acidic hydrolysis, the primary amino alcohol salt is revealed and partitions into the aqueous solution, while the benzophenone byproduct is easily removed by simple extraction with ethyl acetate. These ammonium salts can be directly Boc-protected or further derivatized without isolation to form benzamides and sulfonamides under Schotten-Baumann-type conditions in up to 79% isolated yield over three steps. This methodology has been used to prepare key intermediates for the synthesis of PRMT5 inhibitors with high enantiopurity as well as numerous other amide and sulfonamide derivatives.
Peptidase inhibitors
-
, (2008/06/13)
This invention relates to analogs of peptidase substrates in which the amide group containing the scissile amide bond of the substrate peptide has been replaced by an activated electrophilic ketone moiety. These analogs of the peptidase substrates provide specific enzyme inhibitors for a variety of proteases, the inhibition of which will have useful physiological consequences in a variety of disease states.
