38323-03-4

Basic information

• Product Name: Propanedioic acid, (2-phenylpropylidene)-, diethyl ester
• CAS NO: 38323-03-4
• Molecular Formula: C16H20O4
• Molecular Weight: 276.332
• Mol File: 38323-03-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Propanedioic acid, (2-phenylpropylidene)-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedioic acid, (2-phenylpropylidene)-, diethyl ester(38323-03-4)
• EPA Substance Registry System: Propanedioic acid, (2-phenylpropylidene)-, diethyl ester(38323-03-4)

Safety Data

• Hazardous Substances Data: 38323-03-4(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 34713-70-7 2-Phenylpropanal 
• 105-53-3 diethyl malonate 

Downstream Products

• 252950-62-2 2-hydroxy-8-methyl-3-(2-phenylprop-1-enyl)-4H-pyrido[1,2-a]pyrimidin-4-one 
• 112348-12-6 ethyl 2-ethoxycarbonyl-3-methyl-4-phenylpentanoate 
• 112348-12-6 ethyl 2-ethoxycarbonyl-3-methyl-4-phenylpentanoate 
• 252950-68-8 (+/-)-2,8-methyl-2-phenyl-2,3-dihydro-4-H-furo[2,3-d]-pyrido[1,2-a]-pyrimidin-4-one 
• 112348-14-8 ethyl 3-butyl-2-ethoxycarbonyl-4-phenylpentanoate 
• 112348-14-8 ethyl 3-butyl-2-ethoxycarbonyl-4-phenylpentanoate 

Relevant articles and documents

Organocatalytic Knoevenagel condensation by chiral: C 2-symmetric tertiary diamines

The efficient Knoevenagel condensation catalyzed by (1S,2S)-1,2-diaminocyclohexane derivatives is presented and investigated. Various aliphatic aldehydes undergo condensation with active methylene compounds to yield the corresponding products in high yields. α-Branched aldehydes were found to be efficiently converted to the corresponding enantiomerically enriched products by using these chiral tertiary diamine catalysts.

Highly efficient thermal cyclization reactions of alkylidene esters in continuous flow to give aromatic/heteroaromatic derivatives

Intramolecular thermal cyclization and benzannulation reactions of the Gould-Jacobs and Conrad-Limpach types were performed in a designed continuous flow reactor system at temperatures in the range of 300-360°C and under high pressure conditions (100-160 bar) with very short residence times (0.45-4.5 min) in tetrahydrofuran as a low-boiling point solvent. Substituted heteroaromatic compounds including pyridopyrimidinones and hydroxyquinolines were synthesized in moderate to high yields. Application of the reaction conditions also allows the synthesis of naphthol and biphenyl derivatives. The procedure involves an easy work-up and the non-batchwise preparative synthesis method is suitable for automation.

Electro-organic reactions. Part 49. The synthesis and stereoselective electrochemical hydroxylation of 2,3-dihydro-4H-furo[2,3-d]pyrido[1,2-a]pyrimidin-4-ones

Attempted electrochemical (anodic) hydroxylation of pyridopyrimidine derivatives in the pyridine ring, using trifluoroacetate as nucleophile, fails because enol forms predominate which undergo anodic C-O coupling. Substitution, aimed at precluding enolisa