383365-69-3Relevant academic research and scientific papers
Combining ring-closing metathesis and hydroformylation strategies: A novel approach to spirocyclic γ-butyrolactones
Schmidt,Costisella,Roggenbuck,Westhus,Wildemann,Eilbracht
, p. 7658 - 7665 (2007/10/03)
Di- or tetrahydropyrans with a vinyl side chain are obtained by diastereoselective ring-closing metathesis or by addition of vinylmagnesium chloride to an appropriately functionalized tetrahydropyranone. The resulting allylic alcohols are converted to spirocyclic hemiacetals under hydroformylation conditions. Oxidation yields the corresponding lactones.
