383418-27-7

Basic information

• Product Name: 4-(tert-butyl-dimethyl-silanyloxy)-3-(2-hydroxy-6-methyl-phenylamino)-thiobutyric acid S-ethyl ester
• Synonyms: 4-(tert-butyl-dimethyl-silanyloxy)-3-(2-hydroxy-6-methyl-phenylamino)-thiobutyric acid S-ethyl ester
• CAS NO: 383418-27-7
• Molecular Weight: 383.627
• Mol File: 383418-27-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(tert-butyl-dimethyl-silanyloxy)-3-(2-hydroxy-6-methyl-phenylamino)-thiobutyric acid S-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(tert-butyl-dimethyl-silanyloxy)-3-(2-hydroxy-6-methyl-phenylamino)-thiobutyric acid S-ethyl ester(383418-27-7)
• EPA Substance Registry System: 4-(tert-butyl-dimethyl-silanyloxy)-3-(2-hydroxy-6-methyl-phenylamino)-thiobutyric acid S-ethyl ester(383418-27-7)

Safety Data

• Hazardous Substances Data: 383418-27-7(Hazardous Substances Data)

Upstream product

• 2835-97-4 2-amino-3-methylphenol 
• 63584-41-8 1-ethylthio-1-(trimethylsiloxy)ethene 
• 102191-92-4 tert-butyldimethylsiloxyacetaldehyde 

Downstream Products

• 383418-15-3 Dodecanoic acid [(1R,3R)-1-(tert-butyl-dimethyl-silanyloxymethyl)-3-hydroxy-3-phenyl-propyl]-amide 
• 383418-13-1 dodecanoic acid [1-(tert-butyl-dimethyl-silanyloxymethyl)-3-oxo-3-phenyl-propyl]-amide 

Relevant articles and documents

Revised stereochemistry of ceramide-trafficking inhibitor HPA-12 by X-ray crystallography analysis

In response to Berke?'s report revising the stereochemistry of HPA-12, an important ceramide-trafficking inhibitor that was discovered and synthesized and its stereochemistry determined in 2001, the synthesis and the stereochemistry were reinvestigated. A large-scale synthetic method for HPA-12 based on a Zn-catalyzed asymmetric Mannich-type reaction in water was developed. Single crystals of HPA-12 for X-ray crystallographic analysis were obtained from ethyl propionate/n-hexane, and the stereochemistry was definitely determined to be 1R,3S, consistent with Berke?'s revised structure.