38353-09-2

Basic information

• Product Name: 2-Hydroxypyrimidine hydrochloride
• Synonyms: 2(1H)-PYRIMIDINONE HYDROCHLORIDE;2(1H)-PYRIMIDINONE, MONOHYDROCHLORIDE;2-PYRIMIDINOL HYDROCHLORIDE;2-PYRIMIDINOL MONOHYDROCHLORIDE;2-PYRIMIDINONE HYDROCHLORIDE;2-PYRIMIDONE HYDROCHLORIDE;2-OXOPYRIMIDINE HYDROCHLORIDE;2-HYDROXYPYRIMIDINIUM CHLORIDE
• CAS NO: 38353-09-2
• Molecular Formula: C₄H₅N₂O*Cl
• Molecular Weight: 132.55
• EINECS: 253-897-8
• Product Categories: Pyridines, Pyrimidines, Purines and Pteredines;Pyrimidine;C4 to C5;Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks;Pyrimidines;Heterocycle-Pyrimidine series
• Mol File: 38353-09-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 200-205 °C (dec.)(lit.)
• Boiling Point: 221.2 °C at 760 mmHg
• Flash Point: 87.6 °C
• Appearance: Light yellow to beige/Crystalline Solid
• Density: 1.28 g/cm³
• Vapor Pressure: 0.0889mmHg at 25°C
• Storage Temp.: Store below +30°C.
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Water Solubility: almost transparency
• Sensitive: Hygroscopic
• BRN: 3560963
• CAS DataBase Reference: 2-Hydroxypyrimidine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hydroxypyrimidine hydrochloride(38353-09-2)
• EPA Substance Registry System: 2-Hydroxypyrimidine hydrochloride(38353-09-2)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-40
• Safety Statements: 22-24/25-36-26
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 38353-09-2(Hazardous Substances Data)

Usage

Chemical Properties

light yellow to beige crystalline solid

Uses

2-Hydroxypyrimidine Hydrochloride, is used as a reagent in the synthesis of BI 207524, an indole diamide NS5B thumb pocket 1 inhibitor with improved potency for potential treatment of chronic hepatitis C virus infection.

InChI:InChI=1/C4H4N2O.ClH/c7-4-5-2-1-3-6-4;/h1-3H,(H,5,6,7);1H

Upstream product

• 102-52-3 malonaldehydebis(dimethylacetal) 
• 57-13-6 urea 
• 10132-25-9 2-(ethylsulfanyl)pyrimidine 

Downstream Products

• 1722-12-9 2-chloropyrimidine 
• 52523-24-7 (2R,3R,4R,5R)-2-((benzoyloxy)methyl)-5-(2-oxopyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl dibenzoate 
• 34790-05-1 1-(3,4-dichlorobenzyl)-2(1H)-pyrimidone 
• 22536-67-0 2,5-dichloropyrimidine 
• 52523-22-5 2-trimethylsilyloxypyrimidine 
• 40016-31-7 1-(4-methyl-benzyl)-1H-pyrimidin-2-one 
• 918164-36-0 1-[2-(4-chlorophenyl)-2-oxoethyl]pyrimidin-2(1H)-one 
• 519018-55-4 1-[2-(4-bromophenyl)-2-oxoethyl]pyrimidin-2(1H)-one 
• 312933-52-1 (+/-)-1-[3-[bis(phenylmethyl)amino]-2-hydroxypropyl]-2(1H)pyrimidinone 
• 953720-72-4 2-[2-oxopyrimidin-1(2H)-yl]propanoic acid 
• 1315330-26-7 1-(4-(but-3-yn-1-yloxy)-2-methoxybenzyl)pyriidin-2(1H)-one 
• 63500-40-3 2',3',5'-tri-O-acetyl-zebularine 
• 32779-37-6 2,5-dibromopyrimidine 
• 79387-69-2 5-iodo-2-hydroxypyrimidine 

Relevant articles and documents

Novel and efficient synthesis of 2-aminooxazoles from pyrimidin-2(1H)-one

Stepwise conversion of pyrimidin-2(1H)-one to 2-amino-5-aryloxazoles via oxazolo[3,2-a]pyrimidinium salts is reported. The sequence involves, (i) regioselective N-alkylation of pyrimidone by phenacyl bromides, (ii) cyclization of obtained 1-(2-aryl-2-oxoethyl)pyrimidin-2(1H)-ones into oxazolo[3,2-a] pyrimidinium salts under the action of fuming sulfuric (or triflic) acid, and (iii) reaction of the obtained salts with hydrazine leading to 2-amino-5-aryloxazoles. Georg Thieme Verlag Stuttgart.

O-Alkyl-O-pyrimidin (2)yl-thionophosphonic acid esters

O-Alkyl-O-pyrimidin(2)yl-thionophosphonic acid esters of the formula STR1 in which R is alkyl with 1 to 6 carbon atoms, R' is alkyl with 1 to 6 carbon atoms or phenyl, R" and RIV each independently is hydrogen or alkyl with 1 to 4 carbon atoms, and R'" is halogen or hydrogen. Which possess insecticidal, acaricidal and nematocidal properties.