38358-25-7Relevant academic research and scientific papers
Tandem UPS: Sequential mono- and dialkylation of resin-bound glycine via automated synthesis
Griffith, David L.,O'Donnell, Martin J.,Pottorf, Richard S.,Scott, William L.,Porco Jr., John A.
, p. 8821 - 8824 (1997)
A method has been developed for the synthesis of racemic α,α-disubstituted amino acids by a tandem alkylation process ('Tandem UPS') on solid-support. Consecutive alkylations of Wang resin-bound benzophenone imines of glycine afforded unnatural, disubstituted amino acid derivatives. Automated chemical synthesis was used to efficiently optimize conditions for both formation and hydrolysis of resin-bound disubstituted benzophenone imines and to generate a matrix of disubstituted amino acid derivatives.
