38376-37-3Relevant academic research and scientific papers
Diazole heterocyclic compound and preparation method and application thereof
-
Paragraph 0051; 0052-0055; 0076-0077, (2021/02/10)
The invention relates to the technical field of pesticides, in particular to a diazole heterocyclic compound and a preparation method and application thereof. The diazole heterocyclic compound has anexcellent prevention and treatment effect on plant diseases such as plutella xylostella, myzus persicae and tetranychus urticae, and particularly has a remarkable prevention and treatment effect on plutella xylostella. The compound can be used for preparing insecticides in the fields of agriculture, horticulture and the like and developing novel insecticides without cross resistance, and has goodresearch value and market development prospect.
Syntheses, spectral, X-ray and DFT studies of 5-benzyl-N-phenyl-1,3,4- thiadiazol-2-amine, 2-(5-phenyl-1,3,4-thiadiazol-2-yl) pyridine and 2-(5-methyl-1,3,4-thiadiazole-2-ylthio)-5-methyl-1,3,4-thiadiazole obtained by Mn(II) catalyzed reactions
Dani,Bharty,Kushawaha,Paswan,Prakash, Om,Singh, Ranjan K.,Singh
, p. 251 - 261 (2013/11/19)
New compounds 5-benzyl-N-phenyl-1,3,4-thiadiazol-2-amine (Bptha, 1), 2-(5-phenyl-1,3,4-thiadiazol-2-yl) pyridine (Pthp, 2) and 2-(5-methyl-1,3,4- thiadiazole-2-ylthio)-5-methyl-1,3,4-thiadiazole (Mtmth, 3) have been synthesized and characterized with the aid of elemental analyses, IR, NMR and single crystal X-ray data. The structure of compounds 1, 2 and 3 are stabilized via intramolecular as well as intermolecular hydrogen bonding and crystallize in monoclinic system with space group P 1, P21/n and P 1, respectively. During the course of reaction, the substituted thiosemicarbazide/thiohydrazide get cyclized into the corresponding thiadiazole in the presence of manganese(II) nitrate via loss of H2O to yield compounds 1 and 2. However condensation occurred in the case of 5-methyl-1,3,4-thiadiazole-2-thiol which yielded 2-(5-methyl-1,3,4-thiadiazole-2-ylthio)-5-methyl-1,3,4-thiadiazole (3) by loss of one mole of H2S from two moles of 5-methyl-1,3,4- thiadiazole-2-thiol in the presence of manganese(II) acetate. The geometry optimization has been performed using DFT method and geometrical parameters thus obtained for the compounds have been compared with their single crystal X-ray data. The negative values of HOMO and LUMO energies for the molecules indicate that they are stable. The electronic transition from the ground state to the excited state due to a transfer of electrons from the HOMO to LUMO levels is mainly associated with the πa??π transition.
Dithiocarbamate as an efficient intermediate for the synthesis of 2-amino-1,3,4-thiadiazoles in water
Aryanasab, Fezzeh,Halimehjani, Azim Ziyaei,Saidi, Mohammad R.
supporting information; experimental part, p. 790 - 792 (2010/03/24)
A new and facile protocol for the synthesis of 2-amino-1,3,4-thiadiazoles in water is described. Reaction of acid hydrazides with easily prepared dithiocarbamates gives the corresponding thiadiazoles in moderate to excellent yields. 2-Amino-1,3,4-oxadiazoles were not observed as side products using this procedure.
