383860-01-3Relevant academic research and scientific papers
Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening
Enyedy,Huang,Long,Roller,Yang,Wang,Ling,Nacro,Tomita,Wu,Cao,Guo,Li,Zhu
, p. 4313 - 4324 (2001)
Bcl-2 belongs to a growing family of proteins which regulates programmed cell death (apoptosis). Overexpression of Bcl-2 has been observed in 70% of breast cancer, 30-60% of prostate cancer, 80% of B-cell lymphomas, 90% of colorectal adenocarcinomas, and
Small molecule inhibitors targeted at BCL-2
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, (2008/06/13)
The present invention relates to small molecule antagonists of Bcl-2 family proteins such as Bcl-2 and/or Bcl-XL. In particular, the present invention provides non-peptide cell permeable small molecules (e.g., tricyclo-dibenzo-diazocine-dioxide
