Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening

Article abstract of DOI:10.1021/jm010016f

Bcl-2 belongs to a growing family of proteins which regulates programmed cell death (apoptosis). Overexpression of Bcl-2 has been observed in 70% of breast cancer, 30-60% of prostate cancer, 80% of B-cell lymphomas, 90% of colorectal adenocarcinomas, and