383911-62-4Relevant articles and documents
2-Phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole derivatives: New potent inhibitors of fMLP-induced neutrophil chemotaxis
Bruno, Olga,Brullo, Chiara,Bondavalli, Francesco,Ranise, Angelo,Schenone, Silvia,Falzarano, Maria Sofia,Varani, Katia,Spisani, Susanna
, p. 3696 - 3701 (2007)
It is well known that both acute and chronic autoimmune inflammatory disorders arise following a breakdown in control of neutrophil activation and recruitment. In the search for new anti-inflammatory agents, we synthesized some new 2-phenyl-2,3-dihydro-1H
N-Aryl-2-phenyl-2,3-dihydro-imidazo[1,2-b]pyrazole-1-carboxamides 7-substituted strongly inhibiting both fMLP-OMe- and IL-8-induced human neutrophil chemotaxis
Brullo, Chiara,Spisani, Susanna,Selvatici, Rita,Bruno, Olga
scheme or table, p. 573 - 579 (2012/03/08)
Anomalous activation of neutrophil recruitment is one of the causes of many inflammatory diseases. The chemoattractants N-formyl-methionyl-leucyl- phenylalanine (fMLP), and interleukine 8 (IL8) play a pivotal role in neutrophil chemotaxis regulation in th
Identification of a novel pyrazolo[3,4-d]pyrimidine able to inhibit cell proliferation of a human osteogenic sarcoma in vitro and in a xenograft model in mice
Manetti, Fabrizio,Santucci, Annalisa,Locatelli, Giada A.,Maga, Giovanni,Spreafico, Adriano,Serchi, Tommaso,Orlandini, Maurizio,Bernardini, Giulia,Caradonna, Nicola P.,Spallarossa, Andrea,Brullo, Chiara,Schenone, Silvia,Bruno, Olga,Ranise, Angelo,Bondavalli, Francesco,Hoffmann, Oskar,Bologna, Mauro,Angelucci, Adriano,Botta, Maurizio
, p. 5579 - 5588 (2008/03/27)
New pyrazolo[3,4-d]pyrimidines were synthesized and found to inhibit Src phosphorylation in a cell-free assay. Some of them significantly reduced the growth of human osteogenic sarcoma (SaOS-2) cells. The best compound, in terms of inhibitory properties t