679805-53-9Relevant academic research and scientific papers
Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation
Carraro, Fabio,Naldini, Antonella,Pucci, Annalisa,Locatelli, Giada A.,Maga, Giovanni,Schenone, Silvia,Bruno, Olga,Ranise, Angelo,Bondavalli, Francesco,Brullo, Chiara,Fossa, Paola,Menozzi, Giulia,Mosti, Luisa,Modugno, Michele,Tintori, Cristina,Manetti, Fabrizio,Botta, Maurizio
, p. 1549 - 1561 (2006)
We report here the synthesis of new pyrazolo[3,4-d]pyrimidine derivatives along with their biological properties as inhibitors of isolated Src and cell line proliferation (A431 and 8701-BC cells). Such compounds block the growth of cancer cells by interfe
Structure-based optimization of pyrazolo[3,4-d]pyrimidines as Abl inhibitors and antiproliferative agents toward human leukemia cell lines
Manetti, Fabrizio,Brullo, Chiara,Magnani, Matteo,Mosci, Francesca,Chelli, Beatrice,Crespan, Emmanuele,Schenone, Silvia,Naldini, Antonella,Bruno, Olga,Trincavelli, Maria Letizia,Maga, Giovanni,Carraro, Fabio,Martini, Claudia,Bondavalli, Francesco,Botta, Maurizio
, p. 1252 - 1259 (2008/09/20)
Results from molecular docking calculations and Grid mapping laid the foundations for a structure-based optimization approach to improve the biological properties of pyrazolo-pyrimidine derivatives in terms of inhibition of Abl enzymatic activity and anti
Pyrazolo[3,4-d]pyrimidines Endowed with Antiproliferative Activity on Ductal Infiltrating Carcinoma Cells
Carraro, Fabio,Pucci, Annalisa,Naldini, Antonella,Schenone, Silvia,Bruno, Olga,Ranise, Angelo,Bondavalli, Francesco,Brullo, Chiara,Fossa, Paola,Menozzi, Giulia,Mosti, Luisa,Manetti, Fabrizio,Botta, Maurizio
, p. 1595 - 1598 (2007/10/03)
Novel 1,4,6-trisubstituted pyrazolo[3,4-d]pyrimidines are reported with preliminary in vitro activity data indicating that several of them are potent inhibitors (better than the reference compound) of Src phosphorylation of the breast cancer cells 8701-BC
Antiproliferative activity of new 1-aryl-4-amino-1H-pyrazolo[3,4-d] pyrimidine derivatives toward the human epidermoid carcinoma A431 cell line
Schenone, Silvia,Bruno, Olga,Bondavalli, Francesco,Ranise, Angelo,Mosti, Luisa,Menozzi, Giulia,Fossa, Paola,Donnini, Sandra,Santoro, Annalisa,Ziche, Marina,Manetti, Fabrizio,Botta, Maurizio
, p. 939 - 946 (2007/10/03)
Synthesis and biological evaluation of a new class of 1-aryl-4-amino-1H- pyrazolo[3,4-d]pyrimidine derivatives are reported. A preliminary cellular assay system using the tumor cell line A431 responding to epidermal growth factor (EGF) for its growth, sho
4-SUBSTITUTED DERIVATIVES OF PYRAZOLO[3,4-d]PYRIMIDINE AND PYRROLO[2,3-d]PYRIMIDINE AND USES THEREOF
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Page 2-3; 7, (2008/06/13)
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine are described. Compounds are active as antitumoral agents.
4-SUBSTITUTED DERIVATIVES OF PYRAZOLO[3,4-d]PYRIMIDINE AND PYRROLO[2,3-d]PYRIMIDINE AND USES THEREOF
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Page 9, (2008/06/13)
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine are described. Compounds are active as antitumoural agents.
New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation
Schenone,Bruno,Ranise,Bondavalli,Brullo,Fossa,Mosti,Menozzi,Carraro,Naldini,Bernini,Manetti,Botta
, p. 2511 - 2517 (2007/10/03)
New 4-aminopyrazolo[3,4-d]pyrimidines bearing various substituents at the position 1 and 6, were synthesized. The new compounds showed antiproliferative activity toward A431 cells, were found to be inhibitors of Src phosphorylation, and induced apoptotic
