38398-44-6

Usage

Uses

Used in Pharmaceutical Industry:
5alpha-Pregnan-3alpha,11alpha-diol-20-one is used as an impurity in Alphaxalone (A575530), an anesthetic agent specifically designed for use on animals. As an impurity, it is essential to monitor and control its presence in the final product to ensure the safety, efficacy, and quality of the anesthetic. The presence of 5alpha-Pregnan-3alpha,11alpha-diol-20-one in Alphaxalone may also provide insights into its potential biological effects and possible applications in the development of new pharmaceuticals or therapeutic agents.

Upstream product

• 74578-33-9 20-oxo-5α-pregnan-3β-yl p-tosylate 
• 565-96-8 11α-hydroxy-5β-pregnane-3,20-dione 
• 80-75-1 11-alpha-hydroxyprogesterone 
• 23930-30-5 3α-hydroxy-5α-pregnane-11,20-dione-20-ethylene ketal 
• 150187-23-8 20-oxo-5α-pregnane-3β,11α-diyl 3-acetate 11-cyclohexanecarboxylate 
• 150187-24-9 3β-hydroxy-20-oxo-5α-pregnane-11α-yl cyclohexanecarboxylate 
• 150187-28-3 3α-hydroxy-20-oxo-5α-pregnan-11α-yl 11-cyclohexanecarboxylate 
• 150187-25-0 20-oxo-5α-pregnane-3β,11α-diyl 3-toluenesulfonate 11-cyclohexanecarboxylate 
• 150187-19-2 20,20-ethylenedioxy-3,5-pregnandiene-3,11α-diyl 3-acetate 11-benzoate 
• 150187-22-7 20-oxo-5-pregnene-3β,11α-diyl 3-acetate 11-benzoate 
• 150187-18-1 20-oxo-3,5-pregnandiene-3,11α-diyl 3-acetate 11-benzoate 
• 150187-20-5 20,20-ethylenedioxy-3β-hydroxy-5-pregnen-11α-yl benzoate 
• 150187-21-6 3β-hydroxy-20-oxo-5-pregnen-11α-yl benzoate 
• 104396-80-7 11α-benzoyloxyprogesterone 

Relevant academic research and scientific papers

Allopregnanolone and pregnanolone analogues modified in the C ring: Synthesis and activity

(25R)-3β-Hydroxy-5α-spirostan-12-one (hecogenin) and 11α-hydroxypregn-4-ene-3,20-dione (11α-hydroxyprogesterone) were used as starting materials for the synthesis of a series of 11- and 12-substituted derivatives of 5ξ-pregnanolone (3α-hydroxy-5α- pregnan-20-one and 3α-hydroxy-5β-pregnan-20-one), the principal neurosteroid acting via γ-aminobutyric acid (GABA). These analogues were designed to study the structural requirements of the corresponding GABA A receptor. Their biological activity was measured by in vitro test with [3H]flunitrazepam as radioligand in which allopregnanolone and its active analogues stimulated the binding to the GABAA receptor. Analysis of the SAR data suggests dependence of the flunitrazepam binding activity on the hydrophobic-hydrophilic balance of the groups at the C-ring edge rather than on specific interactions between them and the receptor.

SYNTHESIS OF RIA HAPTENS: 3α,11α-DIHYDROXY-5α-PREGNAN-20-ONE 11-HEMISUCCINATE

5α-Pregnane-3α,11α-diol-20-one (XVII) was prepared by hydroxylation of 5α-pregnan-3α-ol-20-one (XVI) by Rhizopus nigricans and by chemical conversion of 11α-hydroxyprogesterone (I).The diol XVII was partially acylated with 2-(trimethylsilyl)ethyl hydrogen

Anaesthetic steroids of the androstance and pregnane series

Steroids of the androstane and pregnane series possessing a 2α-hydrogen or halogen or an alkyl group; a 3α-hydroxy or acyloxy group, a 3β-hydrogen or alkyl group; an 11β-hydrogen or hydroxy group or an epoxy group linked also to the 9-position; an 11α-hyd