384-83-8

Usage

Uses

Used in Agrochemicals Industry:
2,3,4,5,6-Pentachloro(trifluoromethyl) benzene is used as a key intermediate in the synthesis of various agrochemicals, contributing to the development of effective pest control agents and crop protection products.
Used in Pharmaceuticals Industry:
In the pharmaceutical sector, 2,3,4,5,6-Pentachloro(trifluoromethyl) benzene serves as an intermediate for the production of certain pharmaceuticals, playing a crucial role in the synthesis of compounds with therapeutic applications.
Given its hazardous nature and potential for environmental and health impact, the use of 2,3,4,5,6-Pentachloro(trifluoromethyl) benzene is subject to strict regulation to ensure its safe handling and minimize its release into the environment.

Upstream product

• 98-08-8 α,α,α-trifluorotoluene 
• 75-69-4 trichlorofluoromethane 
• 608-93-5 pentachlorobenzene 
• 2605-69-8 octachlorotoluene 
• 98-56-6 4-chlorobenzotrifluoride 

Downstream Products

• 434-64-0 perfluorotoluene 
• 715-30-0 1-chloro-2,3,4,5-tetrafluoro-6-trifluoromethyl-benzene 
• 1012-84-6 perchlorobenzoic acid 
• 2605-69-8 octachlorotoluene 
• 1825-23-6 pentachlorobenzoyl chloride 
• 13656-40-1 pentachlorobenzoyl fluoride 

Relevant academic research and scientific papers

A method of removing chlorosulfonic acid in pentachlorobenzoyl chloride production

A method of removing chlorosulfonic acid in pentachlorobenzoyl chloride production is disclosed. The method includes (1) feeding chlorine and reacting to produce pentachlorobenzoyl chloride by adopting benzoyl chloride as a raw material and chlorosulfonic acid as a solvent, (2) subjecting the chlorination solution generated in the step (1) to vacuum recovering, (3) cooling the recovered solution to 60-100 DEG C by jacket water cooling, sampling and detecting the content of residual high-oxidizability acids, (4) allowing the mole ratio of sulfuric acid in the recovered solution to sodium chloride to be 1:(2.10-2.5) and reacting the sulfuric acid and the sodium chloride to generate HCl and sodium sulfide, (5) allowing the mole ratio of the chlorosulfonic acid in the recovered solution to sodium bicarbonate to be 1:(0.9-1.0), and (6) allowing the mixture to stand, depositing, centralizing, and subjecting solid to filtration and washing with a solvent to further recover a product. The method has characteristics of cost saving, good product quality, a simple process, easy operation, low environment pollution, and the like.

A New Trifluoromethylating Agent: Synthesis of Polychlorinated (Trifluoromethyl)benzenes and 1,3-Bis(trifluoromethyl)benzenes and Conversion into Their Trichloromethyl Counterparts and Molecular Structure of Highly Strained Polychloro-m-xylenes

Mixtures of CCl3F and AlCl3 replace CF3 for H in polychlorobenzenes.Thus, by treatment of a solution of the suitable polychlorobenzene in CCl3F with AlCl3, the following compounds can be prepared: pentachloro- (2), 2,3,4,5-tetrachloro- (5), 2,3,4,6-tetrachloro- (8), 2,3,5,6-tetrachloro- (11), 2,3,4-trichloro- (14), 2,4,5-trichloro- (17), and 2,4,6-trichloro-1-(trifluoromethyl)benzene (20), as well as 4,5,6-trichloro- (31) and 2,4,6-trichloro-1,3-bis(trifluoromethyl)benzene (32).The reaction of the above-mentioned trifluoromethylated compounds with AlCl3 in CS2 yieldstheir trichloromethyl counterparts: 3, 6, 9, 12, 15, 18, 21, 34, and 36.The chlorination of 32 or 36 by means of Silberrad's reagent (SO2Cl2, AlCl3, and S2Cl2) affords perchloro-m-xylene (38), a new highly strained chlorocarbon whose synthesis was attempted repeatedly in the past. 9, 15, 17, and 21, when treated with oleum and then with water, are converted into 2,3,4,6-tetrachloro- (22), 2,3,4-trichloro- (23), 2,4,5-trichloro- (24), and 2,4,6-trichlorobenzoic acid (25), respectively; under similar treatment, 34, 36, and 38 give 4,5,6-trichloro- (33), 2,4,5-trichloro- (35), and tetrachloroisophthalic acid (39), respectively.The formation of the (trifluoromethyl)benzenes is discussed, and in this connection it has been found that CCl3F solutions of 3 and 18 in the presence of AlCl3 give back 2 and 17, respectively.Molecular structures of highly strained m-xylenes 36 and 38, as well as that of the much less strained 34, ascertained by X-ray analysis, are reported and commented.IR, UV, and NMR spectral data of the compounds synthesized are presented.The interesting UV spectrum of 21 is discussed.

NEW SYNTHESIS OF POLYCHLORO(TRIFLUOROMETHYL)BENZENES AND HIGHLY STRAINED POLYCHLORO(TRICHLOROMETHYL)BENZENES

Several polychloro(trifluoromethyl)benzenes have been prepared by treatment of the corresponding polychlorobenzenes with CCl3F and AlCl3.The resulting trifluoromethyl derivatives, by reaction with the same inorganic halide in CS2, give their trichloromethyl analogues.