38401-38-6

Basic information

• Product Name: Sulfoximine, S-methyl-S-(phenylmethyl)-
• CAS NO: 38401-38-6
• Molecular Formula: C8H11NOS
• Molecular Weight: 169.247
• Mol File: 38401-38-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Sulfoximine, S-methyl-S-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Sulfoximine, S-methyl-S-(phenylmethyl)-(38401-38-6)
• EPA Substance Registry System: Sulfoximine, S-methyl-S-(phenylmethyl)-(38401-38-6)

Safety Data

• Hazardous Substances Data: 38401-38-6(Hazardous Substances Data)

Upstream product

• 766-92-7 [(methylthio)methyl]-benzene 
• 946826-79-5 N-cyano-S-benzyl-S-methylsulfoximine 
• 946826-98-8 N-cyano-S-benzyl-S-methylsulfilimine 
• 952022-15-0 N-(trifluoroacetyl)-S-benzyl-S-methylsulfoximine 
• 824-86-2 benzylmethylsulfoxide 

Downstream Products

• 38401-39-7 S-Benzyl-S-methyl-N-tosylsulfoximin 
• 67069-99-2 S-(1-Brom-1-phenylmethyl)-S-methyl-N-(p-tolylsulfonyl)-sulfoximin 

Relevant articles and documents

One-Pot Synthesis of N-Iodo Sulfoximines from Sulfides

This is the first report on the synthesis and characterization of N-iodo sulfoximines. The synthesis was designed as a room temperature one-pot cascade reaction from readily available sulfides as starting compounds, converted into sulfoximines by reaction with ammonium carbonate and (diacetoxyiodo)benzene, followed by iodination with N-iodosuccinimide or iodine in situ, in up to 90% isolated yields, also at a multigram scale. Iodination of aryls with N-iodo sulfoximines, oxidation, and conversion to N-SCF3 congeners have been demonstrated.

Method for synthesizing sulfoximine compounds from thioether

The invention discloses a synthetic method for synthesizing sulfoximine compounds from thioether in one step and application thereof. The synthetic method disclosed by the invention comprises the step of mixing the thioether, an ammonia source and an organic solvent together for carrying out an oxidizing reaction in the presence of an oxidizing agent, thereby obtaining the corresponding sulfoximine compounds. According to the invention, one-step synthesis of the sulfoximine compounds from the thioether is realized for the first time. In recent years, the sulfoximine structure is introduced into the existing drug molecules or high-activity compound molecules, and many high-activity molecules at the clinical stage and listed drug molecules appear. According to the method disclosed by the invention, the drug molecules containing the sulfoximine structure are produced, and the industrial cost can be greatly reduced; and moreover, the synthetic method provided by the invention has the advantages of being high in yield, readily available in raw materials, simple in conditions, simple in reaction equipment, easy in industrialized production, and the like. The structural formula is as shown in the specification.