946826-79-5

Upstream product

• 946826-98-8 N-cyano-S-benzyl-S-methylsulfilimine 
• 946826-98-8 N-cyano benzyl methyl sulfilimine 
• 766-92-7 [(methylthio)methyl]-benzene 

Downstream Products

• 952022-15-0 N-(trifluoroacetyl)-S-benzyl-S-methylsulfoximine 
• 38401-38-6 [(S-methylsulfonimidoyl)methyl]benzene 

Relevant academic research and scientific papers

Metal-free synthesis of N -cyano-substituted sulfilimines and sulfoximines

Starting from the corresponding sulfides, N-cyano sulfoximines can easily be accessed under metal-free conditions via the corresponding N-cyano-substituted sulfilimines. The reaction sequence involves a sulfide imination with cyanogen amide in presence of a base and N-bromosuccinimide (NBS) followed by an m-chloroperoxybenzoic acid (MCPBA) mediated oxidation of the resulting sulfilimine intermediates.

Synthesis of N-(1H)-tetrazole sulfoximines

N-(1H)-Tetrazole sulfoximines are readily available by addition of sodium azide to the corresponding N-cyano derivatives in the presence of ZnBr 2. The use of these N-(1H)-tetrazoles as intermediates in the synthesis of other N-heterocyclic sulfoximines is demonstrated.

Iodinane- and metal-free synthesis of N-cyano sulfilimines: Novel and easy access of NH-sulfoximines

The synthesis of W-cyanosulfilimines can readily be achieved by reaction of the corresponding sulfides with cyanogen amine in the presence of a base and NBS or l2 as halogenating agents. Oxidation followed by C-N bond cleavage affords synthetically useful WH-free sulfoximines.