38401-73-9

Upstream product

• 4701-17-1 5-bromo-2-thiophencarboxaldehyde 
• 13331-27-6 m-nitrobenzene boronic acid 
• 98-03-3 thiophene-2-carbaldehyde 
• 99-09-2 3-nitro-aniline 

Downstream Products

• 111400-05-6 2,6-Dimethyl-4-[5-(3-nitro-phenyl)-thiophen-2-yl]-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester 
• 38178-61-9 2‐(3‐nitrophenyl)thiophene 
• 111400-08-9 2,6-Dimethyl-4-[5-(3-nitro-phenyl)-thiophen-2-yl]-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 
• 1619995-10-6 9,9-dimethyl-12-[5-(3-nitrophenyl)thiophen-2-yl]-7,8,9,10-tetrahydrobenzo[a]acridin-11(12H)-one 
• 1619995-22-0 (E)-N-[5-(3-nitrophenyl)thiophen-2-ylmethylidene]naphthalen-2-amine 

Relevant academic research and scientific papers

Metal-Free Aerobic Oxidative Selective C-C Bond Cleavage in Heteroaryl-Containing Primary and Secondary Alcohols

A transition-metal-free aerobic oxidative selective C-C bond-cleavage reaction in primary and secondary heteroaryl alcohols is reported. This reaction was highly efficient and tolerated various heteroaryl alcohols, generating a carboxylic acid derivative and a neutral heteroaromatic compound. Experimental studies combined with density functional theory calculations revealed the mechanism underlying the selective C-C bond cleavage. This strategy also provides an alternative simple approach to carboxylation reaction.

Synthesis of 12-hetaryl-9,9-dimethyl-7,8,9,10-tetrahydrobenzo[a]acridin- 11(12H)-ones

Three-component condensation of naphthalen-2-amine with 5-arylfuran(thiophene, N-methylpyrrole)-2-carbaldehyde and 5,5- dimethylcyclohexane-1,3-dione, as well as condensation of N-[(5- arylfuran(thiophen)-2-ylmethylidene]naphthalen-2-amine with 5,5- dimethylcyclohexane-1,3-dione gave the corresponding 12-[5-arylfuran(thiophen, N-methylpyrrol)-2-yl]-7,8,9,10-tetradrobenzo[a]acridin-11(12H)-ones.

Synthesis and reactions of 5-aryl-2-thiophenecarbaldehydes

The reaction of 2-thiophenecarbaldehyde with arene diazonium chlorides in the presence of CuCl2 catalyst gave 5-aryl-2-thiophenecarbaldehydes. Use of 4-nitrobenzene diazonium chloride in the reaction also gave the isomeric 3-(4-nitrophenyl)-2-t

Synthesis of 3-aminorhodanine derivatives as aldose reductase inhibitors

A number of 5-condensated 3-acylaminorhodanines 3 was prepared as potential inhibitors of the aldose reductase by acylation of the amino group of 3-aminorhodanine 1 and subsequent condensation of the 5-methylene function with appropriate aldehydes. Some of these compounds displayed interesting activity.