38406-53-0

Basic information

• Product Name: O-nitro-2-benzamidoethanol
• Synonyms: O-nitro-2-benzamidoethanol
• CAS NO: 38406-53-0
• Molecular Weight: 210.189
• Mol File: 38406-53-0.mol

Chemical Properties

• CAS DataBase Reference: O-nitro-2-benzamidoethanol(CAS DataBase Reference)
• NIST Chemistry Reference: O-nitro-2-benzamidoethanol(38406-53-0)
• EPA Substance Registry System: O-nitro-2-benzamidoethanol(38406-53-0)

Safety Data

• Hazardous Substances Data: 38406-53-0(Hazardous Substances Data)

Upstream product

• 18838-10-3 N-(2-hydroxyethyl)-benzamide 
• 98-88-4 benzoyl chloride 
• 7127-19-7 2-phenyl-1,3-oxazoline 
• 100-47-0 benzonitrile 

Downstream Products

• 88070-48-8 N-methylbenzamide 
• 18838-10-3 N-(2-hydroxyethyl)-benzamide 

Relevant articles and documents

Highly efficient synthesis of β-nitrate ester carboxamides through the ring-opening of 2-oxazolines

A novel method for the synthesis of β-nitrate ester carboxamides using non-corrosive tert-butyl nitrite (TBN) as the nitro source and easily available oxygen as the oxidant has been developed. Variously substituted 2-oxazolines were efficiently ring-opened to deliver the corresponding products in excellent yields. Notably, this reaction provides fast access to pharmaceuticals such as nicorandil.

Nitrate esters in the generation of amino acid radicals

Nitrate esters, prepared by treatment of β-hydroxy-α-amino acid derivatives with nitric acid, react with tributyltin hydride to give the corresponding alkoxyl radicals. These radicals readily undergo β-scission, providing a convenient route for the regiocontrolled production of α-carbon-centred amino acid radicals. By examining the partitioning of the alkoxyl radicals between the β-scission process and the competing hydrogen transfer reaction, it has been possible to evaluate the influence of electronic and steric effects on the β-scission reaction and the formation of the carbon-centred radicals.