38410-64-9Relevant academic research and scientific papers
Miuramides A and B, Trisoxazole Macrolides from a Mycale sp. Marine Sponge That Induce a Protrusion Phenotype in Cultured Mammalian Cells
Suo, Rei,Takada, Kentaro,Kohtsuka, Hisanori,Ise, Yuji,Okada, Shigeru,Matsunaga, Shigeki
, p. 1108 - 1112 (2018)
Morphology-guided cell-based screening of the extract of a Mycale sp. marine sponge led to the isolation of two trisoxazole macrolides, miuramides A (1) and B (2), which induced characteristic morphological changes in 3Y1 cells. The structure of 1 including absolute configuration was elucidated by a combination of the analysis of spectroscopic data, derivatization, and degradation. Both compounds exhibit potent cytotoxicity against 3Y1 cells.
Absolute structure of prunustatin A, a novel GRP78 molecular chaperone down-regulator
Umeda, Yukiko,Furihata, Kazuo,Sakuda, Shohei,Nagasawa, Hiromichi,Ishigami, Ken,Watanabe, Hidenori,Izumikawa, Miho,Takagi, Motoki,Doi, Takayuki,Nakao, Yoichi,Shin-ya, Kazuo
, p. 4239 - 4242 (2007)
In the course of our screening program for regulators of a molecular chaperone GRP78 expression, we isolated a novel inhibitor of GRP78 expression, designated as prunustatin A, from Streptomyces violaceoniger 4521-SVS3. The planar structure of prunustatin
