38425-34-2

Upstream product

• 105-36-2 ethyl bromoacetate 
• 2001-28-7 2-phenyl-1-p-tolyl-ethanone 
• 6921-34-2 benzylmagnesium chloride 
• 20754-20-5 3-p-tolyl-acrylic acid methyl ester 
• 1866-39-3 trans-p-methylcinnamic acid 
• 104-87-0 4-methyl-benzaldehyde 
• 14111-33-2 diethyl 2-(4-methylbenzylidene)malonate 

Downstream Products

• 38425-38-6 1-Methyl-3-(p-tolyl)-tetralin 
• 38425-35-3 3-p-methylphenyl-1-tetralone 

Relevant academic research and scientific papers

Visible-Light Induced C(sp2)?H Amidation with an Aryl–Alkyl σ-Bond Relocation via Redox-Neutral Radical–Polar Crossover

We report an approach for the intramolecular C(sp2)?H amidation of N-acyloxyamides under photoredox conditions to produce δ-benzolactams with an aryl-alkyl σ-bond relocation. Computational studies on the designed reductive single electron transfer strategy led us to identify N-[3,5-bis(trifluoromethyl)benzoyl] group as the most effective amidyl radical precursor. Upon the formation of an azaspirocyclic radical intermediate by the selective ipso-addition with outcompeting an ortho-attack, radical–polar crossover was then rationalized to lead to the rearomative ring-expansion with preferential C?C bond migration.

Synthesis of 3-Aryl-1-tetralones

A new method for the synthesis of 3-aryl-1-tetralones is presented.The tetralones synthesised have been characterised by elemental analysis and soectral data.