38432-77-8 Usage
Description
2-Isopropyl-2-adamantanol, also known as 2-adamantanemethanol, is a chemical compound characterized by its molecular formula C13H22O. It is a tertiary alcohol distinguished by a bulky, adamantane-based structure, which endows it with exceptional stability and resistance to oxidation. This unique molecular configuration and properties render 2-Isopropyl-2-adamantanol a versatile compound for various applications in the fields of organic synthesis, pharmaceuticals, and agrochemicals, as well as in the development of innovative materials and chemical processes.
Uses
Used in Organic Synthesis:
2-Isopropyl-2-adamantanol is utilized as a chiral auxiliary in organic synthesis for its ability to influence the stereochemistry of reactions, leading to the production of enantiomerically pure compounds. Its adamantane-based structure provides a robust and stable platform for asymmetric synthesis, enhancing the efficiency and selectivity of chemical reactions.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 2-Isopropyl-2-adamantanol serves as a valuable precursor for the synthesis of various drugs. Its unique structural features allow for the development of new pharmaceutical compounds with improved therapeutic properties, such as enhanced bioavailability, selectivity, and reduced side effects.
Used in Agrochemicals:
2-Isopropyl-2-adamantanol is also employed in the agrochemical sector as a precursor for the synthesis of novel agrochemicals. Its stable and resistant nature makes it suitable for the development of pesticides and other agrochemicals with increased effectiveness and durability.
Used in Material Science:
The unique adamantane-based structure of 2-Isopropyl-2-adamantanol makes it a promising candidate for the development of new materials with specific properties. It can be used in the creation of advanced materials for various applications, such as high-performance polymers, coatings, and other specialized materials that require stability and resistance to harsh conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 38432-77-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,4,3 and 2 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 38432-77:
(7*3)+(6*8)+(5*4)+(4*3)+(3*2)+(2*7)+(1*7)=128
128 % 10 = 8
So 38432-77-8 is a valid CAS Registry Number.
InChI:InChI=1S/C13H22O/c1-8(2)13(14)11-4-9-3-10(6-11)7-12(13)5-9/h8-12,14H,3-7H2,1-2H3
38432-77-8Relevant articles and documents
Zinc(II)-catalyzed addition of grignard reagents to ketones
Hatano, Manabu,Ito, Orie,Suzuki, Shinji,Ishihara, Kazuaki
supporting information; experimental part, p. 5008 - 5016 (2010/10/04)
(Figure presented) The addition of organometallic reagents to carbonyl compounds has become a versatile method for synthesizing tertiary and secondary alcohols via carbon-carbon bond formation. However, due to the lack of good nucleophilicity or the presence of strong basicity of organometallic reagents, the efficient synthesis of tertiary alcohols from ketones has been particularly difficult and, thus, limited. We recently developed highly efficient catalytic alkylation and arylation reactions to ketones with Grignard reagents (RMgX: R = alkyl, aryl; X = Cl, Br, I) using ZnCl2, Me3SiCH 2MgCl, and LiCl, which effectively minimize problematic side reactions. In principle, RMgBr and RMgI are less reactive than RMgCl for the addition to carbonyl compounds. Therefore, this novel method with homogeneous catalytic ZnCl2·Me3SiCH2MgCl·LiCl is quite attractive, since RMgBr and RMgI, which are easily prepared and/or commercially available, like RMgCl, can be applied successfully. As well as ketones and aldehydes, aldimines were effectively applied to this catalysis, and the corresponding secondary amines were obtained in high yield. With regard to mechanistic details concerning β-silyl effect and salt effect, in situ-prepared [R(Me3SiCH2)2Zn] -[Li]+[MgX2]m[LiCl]n (X = Cl/Br/I) is speculated to be a key catalytic reagent to promote the reaction effectively. The simplicity of this reliable ZnCl2·Me 3SiCH2MgCl·LiCl system in the addition of Grignard reagents to carbonyl compounds might be attractive for industrial as well as academic applications.
