384331-27-5Relevant academic research and scientific papers
The fast and efficient KI/H2O2 mediated 2-sulfonylation of indoles and N-methylpyrrole in water
Zhang, Jun,Wang, Zhong,Chen, Lingjuan,Liu, Yan,Liu, Ping,Dai, Bin
, p. 41651 - 41656 (2019/01/03)
The rapid and efficient KI/H2O2-mediated 2-sulfonylation of substituted indoles and N-methylpyrrole was established. The corresponding 2-sulfonylation products are synthesized from readily available sulfur sources, namely arylsulfonyl hydrazides, 4-methylbenzenesulfinic acid and sodium 4-methylbenzenesulfinate in good to excellent yields in only 5 min. Moreover, the aqueous solution of hydrogen peroxide is used as both oxidant and solvent. Mechanistic studies demonstrated that 2,3-diiodoindoline was the main sulfonylation intermediate.
Convenient KI-catalyzed regioselective synthesis of 2-sulfonylindoles using water as solvent
Li, Hongjie,Wang, Xiaolong,Yan, Jie
supporting information, p. 4277 - 4280 (2017/07/11)
A convenient procedure is developed for the preparation of 2-sulfonylindoles from indoles and sodium sulfinates catalyzed by KI in water. This environmentally benign 2-sulfonylation of indoles proceeds efficiently under mild conditions, affording the products with high regioselectivity and in moderate to good yields.
Regioselective C 2 sulfonylation of indoles mediated by molecular iodine
Katrun, Praewpan,Mueangkaew, Charoensak,Pohmakotr, Manat,Reutrakul, Vichai,Jaipetch, Thaworn,Soorukram, Darunee,Kuhakarn, Chutima
, p. 1778 - 1785 (2014/03/21)
A facile and general method for regioselective C2 sulfonylation reaction of indoles mediated by iodine is described. The 2-sulfonylated products were obtained up to 96% yield under mild reaction conditions (room temperature, 2 h).
Synthesis of new tricyclic melatoninergic ligands
Tsotinis, Andrew,Panoussopoulou, Maria,Sivananthan, Sachi,Sugden, David
, p. 725 - 729 (2007/10/03)
We report the synthesis and biological evaluation of a series of new tricyclic analogs of the hormone melatonin, which act as probes of the constraints at the hormone's receptor site with regard to the lower N1-C2 region of the indole moiety of melatonin.
