384346-15-0Relevant academic research and scientific papers
Spirocyclic compounds, potent CCR1 antagonists
Hossain, Nafizal,Ivanova, Svetlana,Bergare, Jonas,Eriksson, Tomas
, p. 1883 - 1886 (2013/04/10)
Conformationally constrained spirocycles (17-23) and (31-36) were synthesised. In vitro data revealed that these compounds are CCR1 antagonists with sub-nanomolar potency. In a functional assay 22, 23 and 36 inhibited CCR1 mediated chemotaxis with an ICs
NOVEL TRICYCLIC SPIRODERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
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Page/Page column 31-32, (2010/02/11)
The invention provides compounds of formula (I) wherein m, R1, n, R2, q, X, Y, Z, R3, R4, R5, R6, R7, R8, t and R9 are as defined in the specification, proc
NOVEL TRICYCLIC SPIROPIPERIDINES OR SPIROPYRROLIDINES
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, (2008/06/13)
The invention provides compounds of formula (I) wherein m, R1, n, R2, q, X, Y, Z, R3, R4, R5, R6, R7, R8, t and R9 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
