384360-22-9Relevant academic research and scientific papers
Difluoridnated Carbaacyclonucleosides: Synthesis and Evaluation of Antiviral Activity
Lewis, Maureen,Clercq, Erik De
, p. 844 - 856 (2007/10/03)
The synthesis of 4-benzoyloxy-5,5-difluoropentan-1-ol from ethyl difluoroacetate is described. Condensation with pyrimidine bases gave carbaacyclonucleosides. The uracil (8d), cytosine (9) and thymine (10c) congeners were evaluated, and found inactive, in a large variety of antiviral assays.
