38460-57-0Relevant academic research and scientific papers
A dual wavelength polymerization and bioconjugation strategy for high throughput synthesis of multivalent ligands
Li, Zihao,Kosuri, Shashank,Foster, Henry,Cohen, Jarrod,Jumeaux, Coline,Stevens, Molly M.,Chapman, Robert,Gormley, Adam J.
supporting information, p. 19823 - 19830 (2019/12/25)
Structure–function relationships for multivalent polymer scaffolds are highly complex due to the wide diversity of architectures offered by such macromolecules. Evaluation of this landscape has traditionally been accomplished case-by-case due to the experimental difficulty associated with making these complex conjugates. Here, we introduce a simple dual-wavelength, two-step polymerize and click approach for making combinatorial conjugate libraries. It proceeds by incorporation of a polymerization friendly cyclopropenone-masked dibenzocyclooctyne into the side chain of linear polymers or the α-chain end of star polymers. Polymerizations are performed under visible light using an oxygen tolerant porphyrin-catalyzed photoinduced electron/energy transfer-reversible addition–fragmentation chain-transfer (PET-RAFT) process, after which the deprotection and click reaction is triggered by UV light. Using this approach, we are able to precisely control the valency and position of ligands on a polymer scaffold in a manner conducive to high throughput synthesis.
1,3,5-tri-mercapto methyl benzene compound and preparing method thereof
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Paragraph 0040; 0047; 0051; 0055; 0059; 0063; 0066, (2017/10/10)
The invention relates to a 1,3,5-tri-mercapto methyl benzene compound and a preparing method thereof. The preparing method comprises the steps that 1,3,5-tribromomethyl phenyl reacts with thiourea, ethanol-n-butylacetate serves as a solvent to prepare iso
Synthetic study and structure of cage-type cyclophane C36H36S6
Takemura, Hiroyuki,Nagaoka, Maiko,Kawasaki, Chihiro,Tokumoto, Kasumi,Tobita, Noriko,Takano, Yuki,Iwanaga, Tetsuo
, p. 1066 - 1070 (2017/03/31)
A cage compound was synthesized in order to investigate the structure and cation-π interactions of the metal ion complex. The multi-step synthesis was achieved starting from trimesic acid triethyl ester. In solution, a completely symmetrical structure that was anticipated by the molecular design was observed by 1H and 13C NMR spectroscopy. However, in the solid state, X-ray crystallographic analysis revealed that the compound had a collapsed structure.
SYNTHESIS OF CYCLOPHANES FROM A SELF-ASSEMBLY REACTION
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, (2016/06/06)
Disclosed herein is a novel method for preparing cyclophanes, comprising forming a disulfide cyclophane by contacting a linker moiety which includes two or more thiol groups, with a metal salt and an oxidant. The disulfide cyclophane is then desulfurized
Chemical generation and modification of peptides containing multiple dehydroalanines
Morrison, Philip M.,Foley, Patrick J.,Warriner, Stuart L.,Webb, Michael E.
supporting information, p. 13470 - 13473 (2015/09/01)
Chemical formation of dehydroalanine has been widely used for the post-translational modification of proteins and peptides, however methods to incorporate multiple dehydroalanine residues into a single peptide have not been defined. We report the use of methyl 2,5-dibromovalerate which can be used to cleanly carry out this transformation.
