4105-92-4Relevant articles and documents
REACTION OF NUCLEOBASES WITH α-ACETYLENIC ESTERS, POTENTIALLY USEFULL FOR CHEMICAL MODIFICATION OF NUCLEIC ACIDS
Olomucki, M.,Gall, J. Y., Le,Colinart, S.,Durant, F.,Norberg, B.,Evrard, G.
, p. 3471 - 3474 (1984)
The NH2 group and the adjacent ring nitrogen of adenosine and cytidine react with α-acetylenic esters by addition across the triple bond and formation of a lactam with the ester group.
Understanding the Incorporation and Release of Salicylic Acid in Metal-Organic Frameworks for Topical Administration
Rojas, Sara,Horcajada, Patricia
, p. 1325 - 1331 (2021)
Although metal-organic frameworks (MOFs) have been widely demonstrated to be great candidates for drug delivery applications, they have been mainly proposed for the intravenous route. Here, eight highly porous benchmarked MOFs, with different topologies a
Cyclotrimerization of alkynes catalyzed by a self-supported cyclic tri-nuclear nickel(0) complex with α-diimine ligands
Shen, Lingyi,Zhao, Yanxia,Luo, Qiong,Li, Qian-Shu,Liu, Bin,Redshaw, Carl,Wu, Biao,Yang, Xiao-Juan
supporting information, p. 4643 - 4649 (2019/04/05)
A cyclic tri-nuclear α-diimine nickel(0) complex [{Ni(μ-LMe-2,4)}3] (2) was synthesized from a “pre-organized”, trimerized trigonal LNiBr2-type precursor [Ni3(μ2-Br)3(μ3-Br)2(LMe-2,4)3]·Br (1; LMe-2,4 = [(2,4-Me2C6H3)NC(Me)]2). In complex 2, the α-diimine ligands not only exhibit the normal N,N′-chelating mode, but they also act as bridges between the Ni atoms through an unusual π-coordination of a C═N bond to Ni. Complex 2 is able to catalyze the cyclotrimerization of alkynes to form substituted benzenes in good yield and regio-selectivity for the 1,3,5-isomers, which is found to vary with the nature of the alkyne employed. This complex represents a convenient self-supported nickel(0) catalyst with no need for additional ligands and reducing agent.
Cyclotrimerization of phenylacetylene catalyzed by a cobalt half-sandwich complex embedded in an engineered variant of transmembrane protein FhuA
Thiel,Sauer,Mertens,Polen,Chen,Schwaneberg,Okuda
supporting information, p. 5452 - 5456 (2018/08/12)
An (η5-cyclopentadienyl)cobalt(i) complex was covalently incorporated into an engineered variant of the transmembrane protein ferric hydroxamate uptake protein component: A, FhuA ΔCVFtev, using a thiol-ene reaction. A CD spectrum shows the structural integrity of the biohybrid catalyst. MALDI-TOF of the segment containing the anchoring site for the cobalt complex Cys545 confirmed successful conjugation. This biohybrid catalyst catalyzed the cyclotrimerization of phenylacetylene to give a mixture of regioisomeric 1,2,4- and 1,3,5-triphenylbenzene in aqueous medium.