38477-53-1Relevant academic research and scientific papers
Application of salicylic acid as an eco-friendly and efficient catalyst for the synthesis of 2,4,6-triaryl pyridine, 2-amino-3-cyanopyridine, and polyhydroquinoline derivatives
Roozifar, Majid,Hazeri, Nourallah,Faroughi Niya, Homayoun
, p. 1117 - 1129 (2021/02/26)
In this study, three eco-friendly, efficient, and convenient protocols have been reported for one-pot synthesis of 2,4,6-triaryl pyridine, 2-amino-3-cyanopyridine, and polyhydroquinoline derivatives using salicylic acid as a catalyst under solvent-free condition. The reported protocols offer several significant advantages such as the application of a nontoxic, neutral, and cheap catalyst, environmentally friendly conditions, the easy isolation of products by filtering, short reaction times, simple methodology, and good yields.
Triarylimidazo[1,2-a]pyridine-8-carbonitriles: solvent-free synthesis and their anti-cancer evaluation
Gupta, Annah,Sasan, Sonakshi,Kour, Avneet,Nelofar, Nargis,Manikrao Mondhe, Dilip,Kapoor, Kamal K.
supporting information, p. 1813 - 1822 (2019/05/15)
In this study, we have presented the synthesis of novel 2,5,7-triarylimidazo[1,2-a]pyridine-8-carbonitriles from 2-amino-4,6-diarlypyridine-3-carbonitrile and nitrostyrene using FeCl3 (20 mol%) as Lewis acid under solvent-free conditions. A library of compounds with diverse substitutions have also been synthesized and screened for in-vitro anti-cancer activity against various cell lines such as A549 (Lung), HCT-116 (Colon), SW-620 (Colon), and MIAPACA (Pancreas).
CuI@Al2O3 catalyzed synthesis of 2-aminonicotinonitrile derivatives under solvent free condition
Rawat, Manish,Rawat, Diwan S.
supporting information, p. 1153 - 1157 (2019/03/26)
A Green approach for the synthesis of 2-aminonicotinonitriles from oxime acetate as enamine precursor, aldehyde and malononitrile under neat condition without the use of additive in presence of CuI@Al2O3 nanocatalyst is reported. Wid
