384820-97-7

Upstream product

• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 102-50-1 2-methyl-4-methoxyaniline 
• 5367-32-8 5-methoxy-2-nitrotoluene 

Downstream Products

• 384820-79-5 4-(4-chlorobenzylamino)-6-methoxy-8-methylquinoline 
• 384821-02-7 4-hydroxy-6-methoxy-8-methylquinoline 
• 384821-04-9 4-chloro-6-methoxy-8-methylquinoline 

Relevant academic research and scientific papers

BRIDGED BICYCLIC COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS

Novel bridged bicyclic compounds are disclosed herein, along with their pharmaceutically acceptable salts, hydrates and prodrugs. Also disclosed are compositions comprising such compounds, methods of preparing such compounds and methods of using such compounds as antibacterial agents. The disclosed compounds, their pharmaceutically acceptable salts, hydrates and prodrugs, as well as compositions comprising such compounds, salts, hydrates and prodrugs, are useful for treating bacterial infections and associated diseases and conditions.

Synthesis and antibacterial activity of 5- and 6-hydroxy substituted 4-aminoquinolines and derivatives

The synthesis and antimicrobial activity of 4-amino-8-methylquinolines 8, 11 substituted with a hydroxy- or methoxy-group at 5- and at 6-position have been investigated. The title compounds could be prepared by a six-step procedure according to the literature starting from commercially available anilines 1. The novel 4-aminoquinolines 8,11 exhibited slight antibacterial activity against Gram-positive and Gram-negative bacteria.