384835-96-5Relevant articles and documents
The discovery of novel, potent and selective PDE5 inhibitors
Bi, Yingzhi,Stoy, Patrick,Adam, Leonard,He, Bin,Krupinski, John,Normandin, Diane,Pongrac, Ron,Seliger, Laurie,Watson, Andrew,Macor, John E.
, p. 2461 - 2464 (2007/10/03)
The design and synthesis of a novel scaffold for potent and selective PDE5 inhibitors are described. Compound 3a was more potent (PDE5 IC50 = 0.31 nM) and selective (> 10,000-fold vs PDE1 and 160-fold selective vs PDE6) PDE5 inhibitor than sild
