459124-67-5

Upstream product

• 115514-77-7 (3-chloro-4-methoxyphenyl)methanamine 
• 384835-99-8 5-chloro-8-[5-(3-dimethylamino-pyrrolidine-1-sulfonyl)-2-propoxy-phenyl]-2-(4-methoxy-benzyl)-2,7-dihydro-2,3,4,7,9-pentaaza-cyclopenta[a]naphthalen-6-one 
• 384835-99-8 (3R)-1-[[3-(5-chloro-4,8-dihydro-8-[(4-methoxyphenyl)methyl]-4-oxo-1H-pyrazolo[4',3':5,6]pyrido[4,3-d]pyrimidin-2-yl)-4-propoxyphenyl]sulfonyl]-3-(dimethylamino)pyrrolidine 
• 384835-96-5 4-amino-6-chloro-2-(4-methoxy-benzyl)-2H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester 
• 384835-95-4 4,6-dichloro-2-(4-methoxy-benzyl)-2H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester 
• 384835-98-7 4-amino-6-chloro-2-(4-methoxy-benzyl)-2H-pyrazolo[3,4-b]pyridine-5-carboxylic acid amide 
• 384835-97-6 4-amino-6-chloro-2-(4-methoxy-benzyl)-2H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 

Downstream Products

• 384836-03-7 (3R)-1-[[3-[5-[[(3-chloro-4-methoxyphenyl)methyl]amino]-4,8-dihydro-4-oxo-1H-pyrazolo[4',3':5,6]pyrido[4,3-d]pyrimidin-2-yl]-4-propoxyphenyl]sulfonyl]-3-(dimethylamino)pyrrolidine 

Relevant academic research and scientific papers

Pyrazolopyridopyrimidine inhibitors of cGMP phosphodiesterase

Compounds of the formula (I) are useful as inhibitors of cGMP PDE especially Type 5.

The discovery of novel, potent and selective PDE5 inhibitors

The design and synthesis of a novel scaffold for potent and selective PDE5 inhibitors are described. Compound 3a was more potent (PDE5 IC50 = 0.31 nM) and selective (> 10,000-fold vs PDE1 and 160-fold selective vs PDE6) PDE5 inhibitor than sild