3849-22-7

Usage

Uses

Used in Pharmaceutical Industry:
[1(3H)-ISOINDOLINONE-3-YL]ACETIC ACID is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs and improve the efficacy of existing ones.
Used in Agrochemical Industry:
[1(3H)-ISOINDOLINONE-3-YL]ACETIC ACID is used as a component in the production of agrochemicals, such as pesticides and herbicides, due to its potential to enhance the effectiveness of these products.
Used in Materials Science:
[1(3H)-ISOINDOLINONE-3-YL]ACETIC ACID is used as a building block in the development of new materials, including advanced polymers and composites, for its potential to improve material properties and performance.

InChI:InChI=1/C10H9NO3/c12-9(13)5-8-6-3-1-2-4-7(6)10(14)11-8/h1-4,8H,5H2,(H,11,14)(H,12,13)

Upstream product

• 61147-65-7 2-cyano-cinnamic acid 
• 141-82-2 malonic acid 
• 119-67-5 o-carboxybenzaldehyde 
• 27510-48-1 (Z)-3-(2-cyanophenyl)prop-2-enoic acid 
• 131-91-9 1-Nitroso-2-naphthol 
• 14352-51-3 3-iminoisoindolinone 
• 135447-28-8 (3-oxo-isoindolin-1-ylidene)-malonic acid diethyl ester 
• 1354694-26-0 (E)-ethyl 3-(2-carbamoylphenyl)acrylate 
• 55-21-0 benzamide 
• 7468-67-9 o-formylbenzonitrile 
• 1345532-47-9 2-(3-oxo-2,3-dihydro-1H-isoindol-1-yl)malonic acid dimethyl ester 
• 33779-03-2 2-(2-methoxycarbonylethyl)benzoic acid 
• 50620-99-0 alpha-cyanocinnamic acid ethyl ester 
• 14120-21-9 (o-carbamoylbenzoyl)acetic acid 

Downstream Products

• 52952-31-5 tetrabenzoporphyrin 
• 103255-66-9 2-(7-chloro-1,8-naphthyridin-2-yl)-3-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)carbonylmethylisoindolin-1-one 
• 133737-32-3 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone 
• 1404559-32-5 3-{2-[4-(4-fluorophenyl)piperazin-1-yl]-2-oxoethyl}-2,3-dihydro-1H-isoindol-1-one 
• 261624-09-3 benzoatosubphthalocyaninatoboron 
• 935686-58-1 (2-Benzyl-3-oxo-2,3-dihydro-1H-isoindol-1-yl)-acetic acid benzyl ester 
• 210688-56-5 PD 168568 
• 210688-55-4 1,3-dihydro-3-(2-tosylethyl)-2H-isoindol-1-one 

Relevant academic research and scientific papers

Ru(II)-Catalyzed Controlled Cross-Dehydrogenative Coupling of Benzamides with Activated Olefins via Weakly Coordinating Primary Amides

Ru(II)-catalyzed regioselective ortho-alkenylation of primary benzamides with activated olefins has been realized over the competitive cyclized products. This reaction overall proceeds via a cross-dehydrogenative coupling (CDC) reaction using a simple and

BF3·OEt2-Catalyzed Vinyl Azide Addition to in Situ Generated N-Acyl Iminium Salts: Synthesis of 3-Oxoisoindoline-1-acetamides

BF3·OEt2-catalyzed nucleophilic addition of vinyl azides to in situ generated N-acyl iminium salts obtained from 3-hydroxyisoindolinones is described in this article. The procedure is operationally simple, mild, additive, and metal-free. The reaction proceeds smoothly at ambient temperature with a wide range of 3-hydroxyisoindol-1-ones and vinyl azides to afford 3-oxoisoindoline-1-acetamides (32 examples) in high yields (up to 97%). Furthermore, the synthetic utility of this methodology is depicted by exploiting the reactivity of an amide functionality in the products.

Cu/Fe Catalyzed Intermolecular Oxidative Amination of Benzylic C-H Bonds

We report a Cu/Fe co-catalyzed Ritter-type C-H activation/amination reaction that allows efficient and selective intermolecular functionalization of benzylic C-H bonds. This new reaction is featured by simple reaction conditions, readily available reagents and general substrate scope, allowing facile synthesis of biologically interesting nitrogen containing heterocycles. The Cu and Fe salts were found to play distinct roles in this cooperative catalysis. With a little help: A Ritter-type intermolecular amination of benzylic C-H bonds with acetonitrile, co-catalyzed by CuII/FeIII is reported. A wide array of biologically interesting nitrogen containing heterocycles was prepared from 2-alkyl benzoic acids and heteroaromatic carboxylic acids under operationally simple conditions. The Cu and Fe salts were found to play distinct roles in this cooperative catalysis.

Synthesis and pharmacological evaluation of functionalized isoindolinones on GABA-activated chloride currents in rat cerebellum granule cells in culture

A focused N-substituted 3-(2-piperazin-1-yl-2-oxoethyl)-2-(pyridin-2-yl)iso-indolin-1-ones small library was synthesized for modulation of GABA-A receptor function and compared to Zopiclone for the ability to increase GABA-activated chloride currents. All

Cobalt-catalyzed one-pot three-component coupling route to β-acetamido carbonyl compounds: A general synthetic protocol for γ-lactams

An efficient improved procedure for the synthesis of β-acetamido carbonyl compounds is developed by a cobalt(II) chloride-catalyzed three-component coupling protocol. The procedure is also amenable to the synthesis of γ-lactams by a three-component coupli

Isoindolinone enantiomers having affinity for the dopamine D4 receptor

PD 108635 (1) was identified as a potent dopamine D4 ligand and we wanted to replace the benzylic alcohol with a metabolically more stable moiety. Investigations led to the discovery of a series of isoindolinones having D4 affinity.

SYNTHESIS AND SPECTRAL PROPERTIES OF PHTHALIMIDINES AND PHTHALIDES

Alkaline hydrolysis of substituted 2-cyanocinnamic acids leeds to the corresponding substituted 3-carboxymethylphthalimidines; acid hydrolysis of the same acids results in the formation of pfthalides with an analogous structure.NMR and mass spectrometric