210688-55-4Relevant academic research and scientific papers
Isoindolinone enantiomers having affinity for the dopamine D4 receptor
Belliotti, Thomas R.,Brink, Wouter A.,Kesten, Suzanne R.,Rubin, John R.,Wustrow, David J.,Zoski, Kim T.,Whetzel, Steven Z.,Corbin, Ann E.,Pugsley, Thomas A.,Heffner, Thomas G.,Wise, Lawrence D.
, p. 1499 - 1502 (1998)
PD 108635 (1) was identified as a potent dopamine D4 ligand and we wanted to replace the benzylic alcohol with a metabolically more stable moiety. Investigations led to the discovery of a series of isoindolinones having D4 affinity.
Dopamine D4 receptor antagonists
-
, (2011/05/18)
Compounds that are antagonists of dopamine D4 receptors, methods of treating psychosis and schizophrenia using the compounds, and pharmaceutically acceptable compositions that contain the dopamine D4 receptor antagonists are disclosed.
