38505-89-4

Usage

Uses

Used in Organic Synthesis:
2,3-dihydro-2,2'-bisindole is used as a building block in organic synthesis for the creation of complex organic molecules, leveraging its structural features to form novel compounds with potential applications in various fields.
Used in Pharmaceutical Chemistry:
In pharmaceutical chemistry, 2,3-dihydro-2,2'-bisindole is utilized as a key intermediate in the synthesis of pharmaceuticals, contributing to the development of new drugs with diverse therapeutic potentials.
Used in Antitumor Applications:
2,3-dihydro-2,2'-bisindole is employed as an antitumor agent, harnessing its biological activity to target and inhibit the growth of cancer cells, making it a candidate for further research in oncology.
Used in Antimicrobial Applications:
2,3-dihydro-2,2'-bisindole is also used as an antimicrobial agent, where its properties help combat microbial infections, offering a potential alternative or supplement to existing antimicrobial treatments.
Used in Heterocyclic Compound Synthesis:
2,3-dihydro-2,2'-bisindole serves as a precursor in the synthesis of heterocyclic compounds, which are important in the development of pharmaceuticals and other industrial chemicals due to their wide range of biological activities and applications.

Upstream product

• 120-72-9 indole 
• 482-89-3 1H,1H'-2,2'-Biindolylidene-3,3'-dione 
• 172950-81-1 1-acetyl-2,3-dihydro-2,2'-bisindole 
• 69423-26-3 1H,1'H-2,2'--bisindol--3--yl acetate 

Downstream Products

• 199450-21-0 1-benzyl-2-(indol-2'-yl)indole 
• 425376-16-5 1-benzyl-2,3-dihydro-1H,1'H-[2,2']biindolyl 

Relevant academic research and scientific papers

Cu-Catalyzed Radical Addition and Oxidation Cascade: Unsymmetrical Trimerization of Indole to Access Isotriazatruxene

Herein we describe a Cu-catalyzed radical addition and oxidation cascade reaction for the chemo/regioselective synthesis of unsymmetrical indole trimers (isotriazatruxenes, i-TATs) from easily available starting materials. The i-TATs exhibited blue fluorescence in various solvents with different fluorescence intensities and showed good structural expansibility. A wider range of products could be used in optoelectronic materials by developing suitable derivatives.

Short step syntheses of indolo[2,3-a]carbazoles carrying an alkyl, allyl, or a glycosyl group at the 11-position and a novel 6,7-dihydro-13H-cyclopentano[mn]indolo[3,2-c]-acridine derivative

Novel 1-alkyl-, 1-allyl-, and 1-β-glycosyl-2,2′-biindolyls are prepared. Their Diels-Alder reaction produced 11-alkyl-, 11-allyl-, and 11-β-glycosylindolo[2,3-a]carbazoles. Formation of a novel 6,7-dihydro-13H-cyclopentano[mn]indolo[3,2-c]acridine derivative is also reported.

Reduction of indigo: Simple syntheses of 3-acetoxy-, 1-acetyl-2.3-dihydro-, 3-acetoxy-3′-acetyl-, 3-acetoxy-1,3′-diacetyl-2,2′-bisindoles, and 2,2′-bisindole

Indigo was converted to 2,2′-bisindole by the direct reduction with zinc in acetic acid and acetic anhydride under argon or hydrogen atmosphere. Reduction with tin and iron afforded 3-acetoxy-2,2′-bisindole predominantly. Useful building blocks such as 1-acetyl-2,3-dihydro-, 3-acetoxy-3′-acetyl-, and 3-acetoxy-1,3′-diacetyl-2,2′-bisindoles were also produced depending on metal and reaction conditions.

SIMPLE SYNTHESIS OF 2,2'-BISINDOLE FROM INDIGO AND ITS APPLICATION FOR THE SYNTHESIS OF INDOLOPYRROLOCARBAZOLE-5,7-(6H)DIONE AND 5-(6H)ONE DERIVATIVES

Indigo was converted to 2,2'-bisindole, from which 6-substituted indolopyrrolocarbazole-5,7-(6H)dione and -5-(6H)one derivatives were prepared in short steps.Bromination of 6-methylindolopyrrolocarbazole-5,7-(6H)dione is also r