38527-33-2

Upstream product

• 94-09-7 p-aminoethylbenzoate 
• 2526-64-9 dichlorotriphenylphosphorane 
• 38556-93-3 4-azido-benzoic acid ethyl ester 
• 603-35-0 triphenylphosphine 

Downstream Products

• 865073-56-9 ethyl 4-{[(1H-benzotriazol-1-yl)(butylamino)methylidene]amino}benzoate 
• 865073-61-6 ethyl 4-{[bis(1H-benzotriazol-1-yl)methylidene]amino}benzoate 
• 74378-51-1 C₂₈H₂₇NO₂P⁽¹⁺⁾*I^(1-) 
• 10541-82-9 ethyl 4-(methylamino)benzoate 

Relevant academic research and scientific papers

Transient Protection of Organic Azides from Click Reactions with Alkynes by Phosphazide Formation

A method for protecting organic azides from click reactions with alkynes is reported. Treatment of azides with Amphos affords phosphazides, which are stable under click reaction conditions and are easily converted back to azides by treatment with elemental sulfur. Thus, the method allows for facile modification of azide compounds via site-selective click reactions.

Aromatic azido-selective reduction via the staudinger reaction using tri-n-butylphosphonium tetrafluoroborate with triethylamine

An efficient method for the reduction of aromatic azides to anilines via the Staudinger reaction using tri-n-butylphosphonium tetrafluoroborate with triethylamine in aqueous tetrahydrofuran solution is reported. The method enables the aromatic azido-selective reduction of 3-azido-5-(azidomethyl)benzene derivatives to efficiently afford anilines bearing an azidomethyl group.

The preparation of 1,2,3-trisubstituted guanidines

An operationally straightforward and efficient benzotriazole-based method for the guanylation of diverse amines by use of the new reagent classes (bis-benzotriazol-1-yl-methylene)amines 13a-13f and benzotriazole-1- carboxamidines 17a-17i is described. The preparation is described for a variety of both acyclic and cyclic 1,2,3-trisubstituted guanidines in high yields.