38532-90-0

Upstream product

• 2613-89-0 phenylmalonic acid 
• 21759-74-0 ethyl (Z)-3-(benzylamino)-2-butenoate 
• 15781-73-4 di(2,4,6-trichlorophenyl)-2-phenylmalonate 
• 21731-13-5 (E)-3-Benzylamino-but-2-enoic acid ethyl ester 

Downstream Products

• 38468-75-6 1-benzyl-4-hydroxy-6-methyl-3-phenyl-1H-pyridin-2-one 
• 138485-57-1 1-Benzyl-4-hydroxy-2-methyl-6-oxo-5-phenyl-1,6-dihydro-pyridine-3-carboxylic acid 

Relevant academic research and scientific papers

Enantioselective Synthesis of Spiroindenes by Enol-Directed Rhodium(III)-Catalyzed C-H Functionalization and Spiroannulation

Chiral cyclopentadienyl rhodium complexes promote highly enantioselective enol-directed C(sp2)-H functionalization and oxidative annulation with alkynes to give spiroindenes containing all-carbon quaternary stereocenters. High selectivity betwe

Anti-mycobacterial 4-hydroxy-3-phenylpyridin-2(1H)-ones

4-Hydroxy-3-phenylpyridin-2 (1H)-ones with different substituents either at N-1 or in the phenyl group were synthesized by reaction of ethyl β-aminocrotonates with dialkyl malonates or 'magic malonates' (2,4,6-trichlorophenyl malonates).The evaluation of these compounds on Mycobacterium tuberculosis H37Ra, Escherichia coli B and Staphylococcus aureus ATCC 25923 showed significant inhibitory effects on M tuberculosis (5g and 5s, MIC=8μg/ml).A structure-activity relationship is discussed.