385367-13-5

Upstream product

• 62-53-3 aniline 
• 100-52-7 benzaldehyde 
• 538-51-2 benzylidene phenylamine 
• 108749-74-2 N-benzyl-N-phenylcarbamoyl chloride 
• 25333-42-0 (R)-quinuclidin-3-ol 
• 758640-21-0 N-Benzylaniline 

Downstream Products

• 439908-03-9 3-(R)-(benzyl(phenyl)carbamoyloxy)-1-(3-phenylpropyl)-1-azoniabicyclo[2.2.2]octane bromide 
• 439908-01-7 3-(R)-(benzyl(phenyl)carbamoyloxy)-1-phenethyl-1-azoniabicyclo[2.2.2]octane bromide 
• 439908-04-0 3-(R)-(benzyl(phenyl)carbamoyloxy)-1-(2-phenoxyethyl)-1-azoniabicyclo[2.2.2]octane bromide 

Relevant academic research and scientific papers

Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl carbamates as potent and long acting muscarinic antagonists

Novel quaternary ammonium derivatives of N,N-disubstituted (3R)-quinuclidinyl carbamates have been identified as potent M3 muscarinic antagonists with long duration of action in an in vivo model of bronchoconstriction. These compounds have also presented a high level of metabolic transformation (human liver microsomes). The synthesis, structure-activity relationships and biological evaluation of these compounds are reported.

NOVEL QUINUCLIDINE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME

Carbamates of formula (I) or pharmaceutically acceptable salts thereof, including quaternary ammonium salts of formula (II) are disclosed; as well as processes for their preparation, pharmaceutical compositions comprising them and their use in therapy as antagonists of M3 muscarinic receptors.