385440-93-7Relevant articles and documents
IMIDAZO[4,5-C]QUINOLINE COMPOUNDS AND THEIR USE AS ATM KINASE INHIBITORS
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, (2022/05/05)
The present invention relates to imidazo[4,5-c]quinoline compounds and to their use in the inhibition, regulation and/or modulation of signal transduction by ATM kinase and, in particular, for the treatment of ATM mediated diseases, especially cancer.
The synthesis and evaluation of [2.2.1]-bicycloazahydantoins as androgen receptor antagonists
Balog, Aaron,Salvati, Mark E.,Shan, Weifang,Mathur, Arvind,Leith, Leslie W.,Wei, Donna D.,Attar, Ricardo M.,Geng, Jieping,Rizzo, Cheryl A.,Wang, Chihuei,Krystek, Stanley R.,Tokarski, John S.,Hunt, John T.,Gottardis, Marco,Weinmann, Roberto
, p. 6107 - 6111 (2007/10/03)
A novel series of [2.2.1]-bicycloazahydantoins has been designed and synthesized in an enantiospecific manner. Several of these compounds were found to act as antagonists to the androgen receptor. A novel series of [2.2.1]-azahydantoins has been designed
Selective androgen receptor modulators and methods for their identification, design and use
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, (2008/06/13)
Selective androgen receptor modulators (SARMs) having antagonist activity in hormone-dependent tumors while exhibiting no activity or agonist activity against other nontumor tissues containing the androgen receptor as well as methods for identifying, designing and using SARMs are provided.