38557-71-0

Basic information

• Product Name: 2-Chloro-6-methylpyrazine
• Synonyms: 2-CHLORO-6-METHYLPYRAZINE;2-Chloro-6-methylpyrazine 97%;2-Methyl-6-chloropyrazine;6-Methyl-2-chloropyrazine;2-Chloro-6-methyl-1,4-diazine;2-Chloro-6-methylpyrazine, >=98%;2-Chloro-6-methylpyrazine97%
• CAS NO: 38557-71-0
• Molecular Formula: C₅H₅ClN₂
• Molecular Weight: 128.56
• EINECS: C5H5ClN2
• Product Categories: Halides;Pyrazines, Pyrimidines & Pyridazines;Pyrazines, Pyrimidines & Pyridazines
• Mol File: 38557-71-0.mol
• Article Data: 2

Chemical Properties

• Melting Point: 49-52
• Boiling Point: 83°C/35mmHg(lit.)
• Flash Point: 73.337 °C
• Appearance: /
• Density: 1.235 g/cm³
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: -0.89±0.10(Predicted)
• CAS DataBase Reference: 2-Chloro-6-methylpyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-6-methylpyrazine(38557-71-0)
• EPA Substance Registry System: 2-Chloro-6-methylpyrazine(38557-71-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 20/21/22-36/37/38-22
• Safety Statements: 22-26-36/37/39
• WGK Germany: 3
• Hazardous Substances Data: 38557-71-0(Hazardous Substances Data)

Usage

Chemical Properties

Solid

Uses

2-Chloro-6-methylpyrazine was used in the synthesis of palm site inhibitors of HCV NS5B polymerase and potent dipeptidyl peptidase IV inhibitors.

Upstream product

• 109-08-0 2-Methylpyrazine 
• 822-36-6 4-methyl-1H-imidazole 
• 67-66-3 chloroform 

Downstream Products

• 2882-21-5 2-methoxyl-6-methylpyrazine 
• 19848-57-8 2-hydrazino-6-methylpyrazine 
• 1035573-66-0 2-{6-[2-(6-chloro-pyrazin-2-yl)-acetyl]-2,3-dimethoxy-phenoxy}-N-propyl-acetamide 
• 1432909-83-5 methyl 2-(2-chloro-5-methyl-4-(6-methylpyrazin-2-yl)phenyl)acetate 
• 723286-86-0 3-(trifluoromethyl)-5-methyl-[1,2,4]triazolo[4,3-a]pyrazine 
• 5315-24-2 1-(6-methylpyridin-2-yl)hydrazine 
• 1432910-06-9 methyl 2-(2-chloro-4-(6-methylpyrazin-2-yl)phenyl)acetate 
• 723286-87-1 5-methyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine 

Relevant articles and documents

Production method of 2-methyl-3(5 or 6)-methylthio pyrazine

The invention discloses a production method of 2-methyl-3(5 or 6)-methylthio pyrazine. The method comprises the following steps: adding solvents dichloroethane and triethylamine into a reaction kettle, sealing the reaction kettle, introducing chlorine to control the pressure in the kettle at 0.02-0.03 MPa, pumping a methylpyrazine solution into the reaction kettle by using a metering pump, controlling the temperature at 45-60 DEG C, reacting, and transferring reaction liquid(containing the chlorine)in the kettle into a dichloroethane turnover tank through filter pressing for recycling after the reaction is finished; dissolving the residual 2-methyl-3(5 or 6)-chloropyrazine hydrochloride solid in the reaction kettle with water, adjusting the neutrality, and layering to obtain a 2-methyl-3(5or 6)-chloropyrazine crude product; and dropwise adding thechloropyrazine crude product is into sodium methyl mercaptide, performing reflux reaction , and after reaction liquid is extracted, adding an aid into an organic phase to generate a hydrochloride for separating the non-pyrazine product from the product to greatly improve the aroma quality of the obtained product. The product grade is improved, and the whole production process is safe and environmentally friendly.