38559-29-4Relevant academic research and scientific papers
A novel approach to γ-hydroxy-α,β-unsaturated compounds
Krawczyk, Henryk,Wasek, Katarzyna,Kedzia, Jacek
experimental part, p. 3299 - 3306 (2009/05/11)
A simple synthesis of (E)-alk-1-enyl mesylates from (E)-alk-1- enylphosphonates is reported. Construction of γ-hydroxy-α,β- unsaturated compounds was achieved by a two-step process involving dihydroxylation of the enol mesylates followed by HWE reaction of the resulting α-hydroxy aldehydes with activated methylphosphonates. Enantioselective synthesis of the title compounds is also reported.
CARBON-CARBON BOND FORMING REACTION OF BIS(CHLOROMETHYL)SULFONE WITH CARBONYL COMPOUNDS: GENERAL ROUTE TO AROMATIC 2-CHLOROVINYL COMPOUNDS AND α-HYDROXYALDEHYDES
Nagashima, Enkou,Suzuki, Kunio,Ishikawa, Motoaki,Sekiya, Minoru
, p. 1873 - 1879 (2007/10/02)
Bis(chloromethyl)sulfone (1) has been proved to be a useful reagent for the synthesis of aromatic 2-chlorovinyl compounds (4) from aromatic aldehydes and of α-hydroxyaldehydes (5) from aliphatic carbonyl compounds with one carbon prolongation.The sec-butyllithium-aided reaction of 1 with aromatic aldehydes gives 1,3-oxathiolane-3,3-dioxides (2) which are converted to 4 in good yields by thermolysis.On the other hand, the sodium hydride-aided reaction of 1 with aliphatic carbonyl compounds is favorable to the formation of chloromethylsulfonyloxiranes (3).Titanium tetrachloride has been found to be an efficient reagent for hydrolysis of 3 to 5.
Azaspiro compounds
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, (2008/06/13)
This invention relates to a method of using compounds selected from those of the following formula : STR1 wherein R1 is hydrogen, alkyl or alkenyl; R2 is hydrogen, alkyl, cycloalkyl or mononuclear aryl or R1 and R2/s
Azaspiro compounds
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, (2008/06/13)
This invention relates to a method of using compounds of the formula: STR1 wherein R1 is hydrogen, alkyl or alkenyl; R2 is hydrogen, alkyl, cycloalkyl or mononuclear aryl or R1 and R2, taken together with the ca
