385784-46-3Relevant academic research and scientific papers
L-Valine derived chiral N-sulfinamides as effective organocatalysts for the asymmetric hydrosilylation of N-alkyl and N-aryl protected ketimines
Wang, Chao,Wu, Xinjun,Zhou, Li,Sun, Jian
, p. 577 - 582 (2015/02/02)
l-Valine derived N-sulfinamides have been developed as efficient enantioselective Lewis basic organocatalysts for the asymmetric reduction of N-aryl and N-alkyl ketimines with trichlorosilane. Catalyst 3c afforded up to 99% yield and 96% ee in the reduction of N-alkyl ketimines and up to 98% yield and 98% ee in the reduction of N-aryl ketimines.
Scope of the organocatalysed asymmetric reductive amination of ketones with trichlorosilane
Gautier, Franois-Moana,Jones, Simon,Li, Xianfu,Martin, Stephen J.
experimental part, p. 7860 - 7868 (2011/12/02)
A highly active organocatalyst has been shown to affect the asymmetric reductive amination of ketones producing both aromatic and aliphatic amines. At 1 mol% catalyst loading, a series of structurally diverse chiral amines were quickly and economically prepared with good enantioselectivity and generally useful yield. The efficient synthesis of the calcimimetic (+)-NPS R-568 (67%, 89% ee) demonstrated the synthetic applicability of this methodology.
METHOD FOR PRODUCING OPTICALLY ACTIVE BENZYLAMINE DERIVATIVE
-
Page/Page column 21-22, (2008/06/13)
Disclosed is a method for producing an optically active benzylamine derivative which is useful as an intermediate for pharmaceutical products and the like. Specifically, an optically active benzylsulfonylamide derivative as a novel compound is obtained by
