385784-82-7Relevant academic research and scientific papers
Discovery of novel and potent thiazoloquinazolines as selective Aurora A and B kinase inhibitors
Jung, Frédéric H.,Pasquet, Georges,Lambert-Van Der Brempt, Christine,Lohmann, Jean-Jacques M.,Warin, Nicolas,Renaud, Fabrice,Germain, Hervé,De Savi, Chris,Roberts, Nicola,Johnson, Trevor,Dousson, Cyril,Hill, George B.,Mortlock, Andrew A.,Heron, Nicola,Wilkinson, Robert W.,Wedge, Stephen R.,Heaton, Simon P.,Odedra, Rajesh,Keen, Nicholas J.,Green, Stephen,Brown, Elaine,Thompson, Katherine,Brightwell, Stephen
, p. 955 - 970 (2007/10/03)
The synthesis of a novel series of quinazolines substituted at C4 by five-membered ring aminoheterocycles is reported. Their in vitro structure-activity relationships versus Aurora A and B serine-threonine kinases is discussed. Our results demonstrate tha
