385801-77-4Relevant academic research and scientific papers
Application of chiral N,N′-dialkyl-1,2-cyclohexanediamine derivatives in asymmetric copper(II)-catalyzed Henry reactions
Chunhong, Zhao,Liu, Fei,Gou, Shaohua
, p. 278 - 283 (2014/03/21)
A series of chiral N,N′-dialkyl-1,2-cyclohexanediamine derivatives were designed, synthesized, and applied as ligands in asymmetric copper(II)-catalyzed Henry reactions. The catalysts based on such ligands and copper(II) acetate were found to promote asym
Application of rapidly generated bidentate ligand libraries to zinc catalyzed reductions
Zaman, Tariq,Frauenlob, Robin,McCarthy, Robert,Walsh, Carolyn M.,Bergin, Enda
, p. 159 - 166 (2012/11/13)
A methodology for the combinatorial synthesis of bidentate ligands - allowing direct screening of reaction products without the need for isolation or purification - has been employed in a zinc catalyzed hydrosilylation. This reaction allowed the robustness of the methodology to be examined, by employing it in a challenging case where the metal complex is not pre-formed prior to catalysis. Four different ligand families have been examined: imines, aminals, bis-imines and oxazolines and related compounds, with a small library of each type produced and directly screened in the reaction. Three ligands providing enantioselectivities of 50% or more in this very challenging reaction were identified, and ees and conversions were equivalent whether the ligand was obtained as a crude mixture from a library synthesis or as an isolated, purified compound.
Supramolecular-directed chiral induction in biaryl derivatives
Etxebarria,Degenbeck,Felten,Serres,Nieto,Vidal-Ferran
supporting information; experimental part, p. 8794 - 8797 (2010/03/04)
(Chemical Equation Presented) A thermodynamically controlled resolution has allowed for the generation of diastereomerically enriched complexes, by chirality transfer from an enantiopure building block to a dynamically racemic biaryl derivative. A switcha
