38585-61-4

Basic information

• Product Name: 4-(Chloromethyl)-1H-imidazole hydrochloride
• Synonyms: 5-(CHLOROMETHYL)-1H-IMIDAZOLE HYDROCHLORIDE;4-chloromethyl-imidazolhydrochloride;4-Chloromethy-1(3)H-imidazole Hydrochlorid;4-Chloromethy-1H-imidazole Hydrochloride;1H-Imidazole, 4-(chloromethyl)-, monohydrochloride (9CI);4-(Chloromethyl)-1H-imidazole hydrochloride;4-Chloromethyl-1(3)H-imidazole Hydrochloride;1H-IMidazole, 4-(chloroMethyl)-, Monohydrochloride
• CAS NO: 38585-61-4
• Molecular Formula: C₄H₅ClN₂*ClH
• Molecular Weight: 153.01
• Product Categories: Heterocycles
• Mol File: 38585-61-4.mol
• Article Data: 8

Chemical Properties

• Melting Point: 1400C
• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Ethanol, Methanol, Tetrahydrofuran, Toluene
• CAS DataBase Reference: 4-(Chloromethyl)-1H-imidazole hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Chloromethyl)-1H-imidazole hydrochloride(38585-61-4)
• EPA Substance Registry System: 4-(Chloromethyl)-1H-imidazole hydrochloride(38585-61-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 38585-61-4(Hazardous Substances Data)

Usage

Chemical Properties

Beige Solid

Uses

4-Chloromethyl-1H-imidazole Hydrochloride (cas# 38585-61-4) is a compound useful in organic synthesis.

Upstream product

• 32673-41-9 4-hydroxymethyl-1H-imidazole hydrochloride 

Downstream Products

• 79853-10-4 3-(imidazol-4-yl)-2-phenyl-2-(2-pyridyl)-propanenitrile 
• 1258423-02-7 N-((1H-imidazol-5-yl)methyl)-N-(2-(5-chloro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino)-5-methoxyphenyl)methanesulfonamide 
• 145874-66-4 1-(2,4-dinitrophenyl)-3-(chloromethyl)imidazole 
• 78448-25-6 3-(imidazol-4-yl)-2,2-diphenylpropanenitrile 

Relevant articles and documents

Aminooxy analog of histamine is an efficient inhibitor of mammalian l-histidine decarboxylase: Combined in silico and experimental evidence

Histamine plays highlighted roles in the development of many common, emergent and rare diseases. In mammals, histamine is formed by decarboxylation of l-histidine, which is catalyzed by pyridoxal-5′-phosphate (PLP) dependent histidine decarboxylase (HDC, EC 4.1.1.22). The limited availability and stability of the protein have delayed the characterization of its structure-function relationships. Our previous knowledge on mammalian HDC, derived from both in silico and experimental approaches, indicates that an effective competitive inhibitor should be capable to form an "external aldimine-like structure" and have an imidazole group, or its proper mimetic, which provides additional affinity of PLP-inhibitor adduct to the HDC active center. This is confirmed using HEK-293 cells transfected to express human HDC and the aminooxy analog of histidine, 4(5)-aminooxymethylimidazole (O-IMHA, IC50 ≈ 2 × 10-7M) capable to form a PLP-inhibitor complex (oxime) in the enzyme active center. Taking advantage of the availability of the human HDC X-ray structure, we have also determined the potential interactions that could stabilize this oxime in the active site of mammalian HDC.

THIAZOLOPYRIDINONE DERIVATES AS MCH RECEPTOR ANTAGONISTS

The present invention relates to a melanin concentrating hormone antagonist compound of formula (I); wherein w, R1, q, p, R2, t, Ar1, L1, R3 and R4 are as defined, or a pharmaceutically acceptable salt, solvate, or enantiomer thereof useful in the treatment, prevention or amelioration of symptoms associated with obesity and related diseases.

Cholecystokinin antagonists

Benzodiazepine analogs of the formula: STR1 are disclosed which are antagonists of gastrin and cholecystokinin (CCK).