38585-66-9Relevant academic research and scientific papers
Formation of Two 4-Imidazolylmethylphosphonium Salts and their Synthetic Studies Toward Histamine H3-Ligands
Harusawa, Shinya,Kawamura, Makoto,Koyabu, Shuji,Hosokawa, Tomoko,Araki, Lisa,Sakamoto, Yasuhiko,Hashimoto, Takeshi,Yamamoto, Yumiko,Yamatodani, Atsushi,Kurihara, Takushi
, p. 2844 - 2850 (2003)
A simple and convenient preparation of {[1H-imidazol-4(5)-yl]methyl} triphenylphosphonium chloride (5) is described. The phosphonium salt 5 could be applied to the synthesis of 1-[1H-imidazol-4(5)-yl]-5-arylpentan- or 6-arylhexan-3-ones 4a-d exhibiting histamine H3-antagonistic activities via a 1,3-diazafulvene intermediate 6 generated from 5. Further, two-methylene-enlongated homolog 3 of imifuramine was efficiently synthesized, starting from Wittig olefination of aldehyde 24 using [(1-tritylimidazol-4-yl) methyl]triphenylphosphonium chloride 7.
